Cargando…

Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation

Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg(...

Descripción completa

Detalles Bibliográficos
Autores principales: Shuai, Cijun, Li, Sheng, Peng, Shuping, Yang, Youwen, Gao, Chengde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Whioce Publishing Pte. Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415857/
https://www.ncbi.nlm.nih.gov/pubmed/32782985
http://dx.doi.org/10.18063/ijb.v6i1.248
_version_ 1783569216650084352
author Shuai, Cijun
Li, Sheng
Peng, Shuping
Yang, Youwen
Gao, Chengde
author_facet Shuai, Cijun
Li, Sheng
Peng, Shuping
Yang, Youwen
Gao, Chengde
author_sort Shuai, Cijun
collection PubMed
description Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg(2)Si was incorporated into Fe matrix through selective laser melting and readily hydrolyzed in a physiological environment, thereby exposing more surface area of Fe matrix to the solution. Moreover, the gaseous hydrolytic products of Mg(2)Si acted as an expanding agent and cracked the dense degradation product layers of Fe matrix, which offered rapid access for solution invasion and corrosion propagation toward the interior of Fe matrix. This resulted in the breakdown of protective degradation product layers and even the direct peeling off of Fe matrix. Consequently, the degradation rate for Fe/Mg(2)Si composites (0.33 mm/y) was significantly improved in comparison with that of Fe (0.12 mm/y). Meanwhile, Fe/Mg(2)Si composites were found to enable the growth and proliferation of MG-63 cells, showing good cytocompatibility. This study indicated that hydrolytic expansion may be an effective strategy to accelerate the degradation of Fe-based implants.
format Online
Article
Text
id pubmed-7415857
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Whioce Publishing Pte. Ltd.
record_format MEDLINE/PubMed
spelling pubmed-74158572020-08-10 Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation Shuai, Cijun Li, Sheng Peng, Shuping Yang, Youwen Gao, Chengde Int J Bioprint Research Article Fe is regarded as a promising bone implant material due to inherent degradability and high mechanical strength, but its degradation rate is too slow to match the healing rate of bone. In this work, hydrolytic expansion was cleverly exploited to accelerate Fe degradation. Concretely, hydrolyzable Mg(2)Si was incorporated into Fe matrix through selective laser melting and readily hydrolyzed in a physiological environment, thereby exposing more surface area of Fe matrix to the solution. Moreover, the gaseous hydrolytic products of Mg(2)Si acted as an expanding agent and cracked the dense degradation product layers of Fe matrix, which offered rapid access for solution invasion and corrosion propagation toward the interior of Fe matrix. This resulted in the breakdown of protective degradation product layers and even the direct peeling off of Fe matrix. Consequently, the degradation rate for Fe/Mg(2)Si composites (0.33 mm/y) was significantly improved in comparison with that of Fe (0.12 mm/y). Meanwhile, Fe/Mg(2)Si composites were found to enable the growth and proliferation of MG-63 cells, showing good cytocompatibility. This study indicated that hydrolytic expansion may be an effective strategy to accelerate the degradation of Fe-based implants. Whioce Publishing Pte. Ltd. 2020-01-23 /pmc/articles/PMC7415857/ /pubmed/32782985 http://dx.doi.org/10.18063/ijb.v6i1.248 Text en Copyright: © 2020 Shuai, et al. http://creativecommons.org/licenses/cc-by-nc/4.0/ This is an open-access article distributed under the terms of the Attribution-NonCommercial 4.0 International 4.0 (CC BY-NC 4.0), which permits all non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Research Article
Shuai, Cijun
Li, Sheng
Peng, Shuping
Yang, Youwen
Gao, Chengde
Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation
title Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation
title_full Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation
title_fullStr Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation
title_full_unstemmed Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation
title_short Hydrolytic Expansion Induces Corrosion Propagation for Increased Fe Biodegradation
title_sort hydrolytic expansion induces corrosion propagation for increased fe biodegradation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415857/
https://www.ncbi.nlm.nih.gov/pubmed/32782985
http://dx.doi.org/10.18063/ijb.v6i1.248
work_keys_str_mv AT shuaicijun hydrolyticexpansioninducescorrosionpropagationforincreasedfebiodegradation
AT lisheng hydrolyticexpansioninducescorrosionpropagationforincreasedfebiodegradation
AT pengshuping hydrolyticexpansioninducescorrosionpropagationforincreasedfebiodegradation
AT yangyouwen hydrolyticexpansioninducescorrosionpropagationforincreasedfebiodegradation
AT gaochengde hydrolyticexpansioninducescorrosionpropagationforincreasedfebiodegradation