Treatment with Volanesorsen, a 2′-O-Methoxyethyl-Modified Antisense Oligonucleotide Targeting APOC3 mRNA, Does Not Affect the QTc Interval in Healthy Volunteers

The aim of this study was to assess the effect of volanesorsen on the corrected QT (QTc) interval. This thorough QT study enrolled 52 healthy male and female subjects who were randomized at a single site in a four-way crossover study. Subjects were randomly assigned to 1 of 12 treatment sequences an...

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Detalles Bibliográficos
Autores principales: Watts, Lynnetta M., Karwatowska-Prokopczuk, Ewa, Hurh, Eunju, Alexander, Veronica J., Balogh, Kristin, O'Dea, Louis, Geary, Richard S., Tsimikas, Sotirios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415887/
https://www.ncbi.nlm.nih.gov/pubmed/32589506
http://dx.doi.org/10.1089/nat.2019.0837

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415887/
https://www.ncbi.nlm.nih.gov/pubmed/32589506
http://dx.doi.org/10.1089/nat.2019.0837

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