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The Presence of Urinary Ketones according to Metabolic Status and Obesity

BACKGROUND: Recently, new concepts about obesity and normal weight subtypes with metabolic conditions are rising and ketone bodies are emerging as a significant indicator of metabolic health. This study aimed to find a relationship between ketonuria and those subtypes. METHODS: The data of 19,036 su...

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Autores principales: Kim, Bo-Reum, Seo, Jeong Woo, Kim, Sang Man, Kim, Kyu-Nam, Joo, Nam-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416001/
https://www.ncbi.nlm.nih.gov/pubmed/32776723
http://dx.doi.org/10.3346/jkms.2020.35.e273
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author Kim, Bo-Reum
Seo, Jeong Woo
Kim, Sang Man
Kim, Kyu-Nam
Joo, Nam-Seok
author_facet Kim, Bo-Reum
Seo, Jeong Woo
Kim, Sang Man
Kim, Kyu-Nam
Joo, Nam-Seok
author_sort Kim, Bo-Reum
collection PubMed
description BACKGROUND: Recently, new concepts about obesity and normal weight subtypes with metabolic conditions are rising and ketone bodies are emerging as a significant indicator of metabolic health. This study aimed to find a relationship between ketonuria and those subtypes. METHODS: The data of 19,036 subjects were analyzed in this cross-sectional study (2013–2017 Korea National Health and Nutrition Examination Survey, KNHANES). Based on body mass index and adult treatment panel III with modification of waist circumference, individuals were categorized into 4 groups: metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obese (MUO). Individuals were divided into 2 groups, positive and negative ketonuria groups, and the metabolic parameters were compared. RESULTS: The metabolic indicators of the positive ketonuria group showed better results than those of the negative ketonuria group and the MHNW group showed the highest proportion of positive ketonuria. The MHNW group showed higher urinary ketones than the MUO group (odds ratio [OR], 0.391; 95% confidence interval [CI], 0.254–0.601) in men. In women, OR of having ketonuria was 0.698 (95% CI, 0.486–1.002) in the MHO group and 0.467 (95% CI, 0.226–0.966) in the MUNW group compared to the MHNW group, respectively. CONCLUSION: Compared to the MHNW group, the MUO group showed lower presence of ketonuria in men, and tendency to have less ketonuria in women.
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spelling pubmed-74160012020-08-17 The Presence of Urinary Ketones according to Metabolic Status and Obesity Kim, Bo-Reum Seo, Jeong Woo Kim, Sang Man Kim, Kyu-Nam Joo, Nam-Seok J Korean Med Sci Original Article BACKGROUND: Recently, new concepts about obesity and normal weight subtypes with metabolic conditions are rising and ketone bodies are emerging as a significant indicator of metabolic health. This study aimed to find a relationship between ketonuria and those subtypes. METHODS: The data of 19,036 subjects were analyzed in this cross-sectional study (2013–2017 Korea National Health and Nutrition Examination Survey, KNHANES). Based on body mass index and adult treatment panel III with modification of waist circumference, individuals were categorized into 4 groups: metabolically healthy normal weight (MHNW), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obese (MUO). Individuals were divided into 2 groups, positive and negative ketonuria groups, and the metabolic parameters were compared. RESULTS: The metabolic indicators of the positive ketonuria group showed better results than those of the negative ketonuria group and the MHNW group showed the highest proportion of positive ketonuria. The MHNW group showed higher urinary ketones than the MUO group (odds ratio [OR], 0.391; 95% confidence interval [CI], 0.254–0.601) in men. In women, OR of having ketonuria was 0.698 (95% CI, 0.486–1.002) in the MHO group and 0.467 (95% CI, 0.226–0.966) in the MUNW group compared to the MHNW group, respectively. CONCLUSION: Compared to the MHNW group, the MUO group showed lower presence of ketonuria in men, and tendency to have less ketonuria in women. The Korean Academy of Medical Sciences 2020-07-20 /pmc/articles/PMC7416001/ /pubmed/32776723 http://dx.doi.org/10.3346/jkms.2020.35.e273 Text en © 2020 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Bo-Reum
Seo, Jeong Woo
Kim, Sang Man
Kim, Kyu-Nam
Joo, Nam-Seok
The Presence of Urinary Ketones according to Metabolic Status and Obesity
title The Presence of Urinary Ketones according to Metabolic Status and Obesity
title_full The Presence of Urinary Ketones according to Metabolic Status and Obesity
title_fullStr The Presence of Urinary Ketones according to Metabolic Status and Obesity
title_full_unstemmed The Presence of Urinary Ketones according to Metabolic Status and Obesity
title_short The Presence of Urinary Ketones according to Metabolic Status and Obesity
title_sort presence of urinary ketones according to metabolic status and obesity
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416001/
https://www.ncbi.nlm.nih.gov/pubmed/32776723
http://dx.doi.org/10.3346/jkms.2020.35.e273
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