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Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome
Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder that typically occurs in the limbs, usually the upper limb. CRPS usually develops from a peripheral event but its maintenance relies on changes within the central nervous system. While functional abnormalities in the thalam...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416050/ https://www.ncbi.nlm.nih.gov/pubmed/32510695 http://dx.doi.org/10.1002/hbm.25087 |
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author | Di Pietro, Flavia Lee, Barbara Henderson, Luke A. |
author_facet | Di Pietro, Flavia Lee, Barbara Henderson, Luke A. |
author_sort | Di Pietro, Flavia |
collection | PubMed |
description | Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder that typically occurs in the limbs, usually the upper limb. CRPS usually develops from a peripheral event but its maintenance relies on changes within the central nervous system. While functional abnormalities in the thalamus and primary somatosensory cortex (S1) of the brain are some of the most consistently reported brain findings in CRPS, the mechanisms are yet to be explored in full, not least of all how these two regions interact and how they might relate to clinical deficits, such as the commonly reported poor tactile acuity in this condition. This study recruited 15 upper‐limb CRPS subjects and 30 healthy controls and used functional magnetic resonance imaging (fMRI) to investigate infra‐slow oscillations (ISOs) in critical pain regions of the brain in CRPS. As hypothesised, we found CRPS was associated with increases in resting signal intensity ISOs (0.03–0.06 Hz) in the thalamus contralateral to the painful limb in CRPS subjects. Interestingly, there was no such difference between groups in S1, however CRPS subjects displayed stronger thalamo‐S1 functional connectivity than controls, and this was related to pain. As predicted, CRPS subjects displayed poor tactile acuity on the painful limb which, interestingly, was also related to thalamo‐S1 functional connectivity strength. Our findings provide novel evidence of altered patterns of resting activity and connectivity in CRPS which may underlie altered thalamocortical loop dynamics and the constant perception of pain. |
format | Online Article Text |
id | pubmed-7416050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74160502020-08-10 Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome Di Pietro, Flavia Lee, Barbara Henderson, Luke A. Hum Brain Mapp Research Articles Complex regional pain syndrome (CRPS) is a chronic neuropathic pain disorder that typically occurs in the limbs, usually the upper limb. CRPS usually develops from a peripheral event but its maintenance relies on changes within the central nervous system. While functional abnormalities in the thalamus and primary somatosensory cortex (S1) of the brain are some of the most consistently reported brain findings in CRPS, the mechanisms are yet to be explored in full, not least of all how these two regions interact and how they might relate to clinical deficits, such as the commonly reported poor tactile acuity in this condition. This study recruited 15 upper‐limb CRPS subjects and 30 healthy controls and used functional magnetic resonance imaging (fMRI) to investigate infra‐slow oscillations (ISOs) in critical pain regions of the brain in CRPS. As hypothesised, we found CRPS was associated with increases in resting signal intensity ISOs (0.03–0.06 Hz) in the thalamus contralateral to the painful limb in CRPS subjects. Interestingly, there was no such difference between groups in S1, however CRPS subjects displayed stronger thalamo‐S1 functional connectivity than controls, and this was related to pain. As predicted, CRPS subjects displayed poor tactile acuity on the painful limb which, interestingly, was also related to thalamo‐S1 functional connectivity strength. Our findings provide novel evidence of altered patterns of resting activity and connectivity in CRPS which may underlie altered thalamocortical loop dynamics and the constant perception of pain. John Wiley & Sons, Inc. 2020-06-08 /pmc/articles/PMC7416050/ /pubmed/32510695 http://dx.doi.org/10.1002/hbm.25087 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Di Pietro, Flavia Lee, Barbara Henderson, Luke A. Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome |
title | Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome |
title_full | Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome |
title_fullStr | Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome |
title_full_unstemmed | Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome |
title_short | Altered resting activity patterns and connectivity in individuals with complex regional pain syndrome |
title_sort | altered resting activity patterns and connectivity in individuals with complex regional pain syndrome |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416050/ https://www.ncbi.nlm.nih.gov/pubmed/32510695 http://dx.doi.org/10.1002/hbm.25087 |
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