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Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults
Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma‐aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the rol...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416055/ https://www.ncbi.nlm.nih.gov/pubmed/32583940 http://dx.doi.org/10.1002/hbm.25041 |
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author | King, Bradley R. Rumpf, Jost‐Julian Verbaanderd, Elvire Heise, Kirstin F. Dolfen, Nina Sunaert, Stefan Doyon, Julien Classen, Joseph Mantini, Dante Puts, Nicolaas A. J. Edden, Richard A. E. Albouy, Geneviève Swinnen, Stephan P. |
author_facet | King, Bradley R. Rumpf, Jost‐Julian Verbaanderd, Elvire Heise, Kirstin F. Dolfen, Nina Sunaert, Stefan Doyon, Julien Classen, Joseph Mantini, Dante Puts, Nicolaas A. J. Edden, Richard A. E. Albouy, Geneviève Swinnen, Stephan P. |
author_sort | King, Bradley R. |
collection | PubMed |
description | Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma‐aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor learning in healthy older adults, a knowledge gap that is surprising given the established aging‐related reductions in sensorimotor GABA. Here, we examined the effects of motor learning and subsequent tDCS on sensorimotor GABA levels and resting‐state functional connectivity in the brains of healthy older participants. Thirty‐six older men and women completed a motor sequence learning task before receiving anodal or sham tDCS to the sensorimotor cortex. GABA‐edited magnetic resonance spectroscopy of the sensorimotor cortex and resting‐state (RS) functional magnetic resonance imaging data were acquired before and after learning/stimulation. At the group level, neither learning nor anodal tDCS significantly modulated GABA levels or RS connectivity among task‐relevant regions. However, changes in GABA levels from the baseline to post‐learning session were significantly related to motor learning magnitude, age, and baseline GABA. Moreover, the change in functional connectivity between task‐relevant regions, including bilateral motor cortices, was correlated with baseline GABA levels. These data collectively indicate that motor learning‐related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels and who learn the most. Post‐learning tDCS exerted no influence on GABA levels, functional connectivity or the relationships among these variables in older adults. |
format | Online Article Text |
id | pubmed-7416055 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74160552020-08-10 Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults King, Bradley R. Rumpf, Jost‐Julian Verbaanderd, Elvire Heise, Kirstin F. Dolfen, Nina Sunaert, Stefan Doyon, Julien Classen, Joseph Mantini, Dante Puts, Nicolaas A. J. Edden, Richard A. E. Albouy, Geneviève Swinnen, Stephan P. Hum Brain Mapp Research Articles Previous research in young adults has demonstrated that both motor learning and transcranial direct current stimulation (tDCS) trigger decreases in the levels of gamma‐aminobutyric acid (GABA) in the sensorimotor cortex, and these decreases are linked to greater learning. Less is known about the role of GABA in motor learning in healthy older adults, a knowledge gap that is surprising given the established aging‐related reductions in sensorimotor GABA. Here, we examined the effects of motor learning and subsequent tDCS on sensorimotor GABA levels and resting‐state functional connectivity in the brains of healthy older participants. Thirty‐six older men and women completed a motor sequence learning task before receiving anodal or sham tDCS to the sensorimotor cortex. GABA‐edited magnetic resonance spectroscopy of the sensorimotor cortex and resting‐state (RS) functional magnetic resonance imaging data were acquired before and after learning/stimulation. At the group level, neither learning nor anodal tDCS significantly modulated GABA levels or RS connectivity among task‐relevant regions. However, changes in GABA levels from the baseline to post‐learning session were significantly related to motor learning magnitude, age, and baseline GABA. Moreover, the change in functional connectivity between task‐relevant regions, including bilateral motor cortices, was correlated with baseline GABA levels. These data collectively indicate that motor learning‐related decreases in sensorimotor GABA levels and increases in functional connectivity are limited to those older adults with higher baseline GABA levels and who learn the most. Post‐learning tDCS exerted no influence on GABA levels, functional connectivity or the relationships among these variables in older adults. John Wiley & Sons, Inc. 2020-06-25 /pmc/articles/PMC7416055/ /pubmed/32583940 http://dx.doi.org/10.1002/hbm.25041 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles King, Bradley R. Rumpf, Jost‐Julian Verbaanderd, Elvire Heise, Kirstin F. Dolfen, Nina Sunaert, Stefan Doyon, Julien Classen, Joseph Mantini, Dante Puts, Nicolaas A. J. Edden, Richard A. E. Albouy, Geneviève Swinnen, Stephan P. Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults |
title | Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults |
title_full | Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults |
title_fullStr | Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults |
title_full_unstemmed | Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults |
title_short | Baseline sensorimotor GABA levels shape neuroplastic processes induced by motor learning in older adults |
title_sort | baseline sensorimotor gaba levels shape neuroplastic processes induced by motor learning in older adults |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416055/ https://www.ncbi.nlm.nih.gov/pubmed/32583940 http://dx.doi.org/10.1002/hbm.25041 |
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