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Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study

BACKGROUND: When using low-energy electron beams for the treatment of skin lesions, such as Mycosis Fungoides (MF), a beam spoiler is used to decrease electron therapeutic depth (R(90)) while increasing the surface dose. OBJECTIVE: The aim of this study was to evaluate the characteristics of a 5 MeV...

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Autores principales: S., Noshadi, M., Atarod, A., Amouheidari, F., Felfeliyan, P., Shokrani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416096/
https://www.ncbi.nlm.nih.gov/pubmed/32802792
http://dx.doi.org/10.31661/jbpe.v0i0.712
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author S., Noshadi
M., Atarod
A., Amouheidari
F., Felfeliyan
P., Shokrani
author_facet S., Noshadi
M., Atarod
A., Amouheidari
F., Felfeliyan
P., Shokrani
author_sort S., Noshadi
collection PubMed
description BACKGROUND: When using low-energy electron beams for the treatment of skin lesions, such as Mycosis Fungoides (MF), a beam spoiler is used to decrease electron therapeutic depth (R(90)) while increasing the surface dose. OBJECTIVE: The aim of this study was to evaluate the characteristics of a 5 MeV electron beam when using a spoiler for the local treatment of MF skin lesions by Monte Carlo (MC) simulation. MATERIAL AND METHODS: In this experimental study, a Siemens Primus treatment head and an acrylic spoiler, positioned at the end of applicator, were simulated using BEAMnrc, an EGSnrc user code. The modelled beam was validated by measurement using MP3-M water tank, Roos parallel plate chamber and Semi flex Chamber-31013 (all from PTW, Freiburg, Germany). For different spoiler thicknesses, dose distributions in water were calculated for 2 field sizes and were compared to those for the corresponding open fields. RESULTS: For a 1.3 cm spoiler, therapeutic range changed from 1.5 cm (open field) to 0.5 cm and 0.4 cm for 10 × 10 cm(2) and 20 × 20 cm(2) field sizes, respectively. Maximum increase in penumbra width was 2.8 and 3.8 cm for 10 × 10 cm(2) and 20 × 20 cm(2) field sizes, respectively. Maximum increase in bremsstrahlung contamination was %2 in both field sizes. CONCLUSION: R(90) decreased exponentially with increase in spoiler thickness. The effect of field size on penumbra was much larger for spoiled beam compared to the open beam. The results of this research can be applied to optimize the radiation treatment of MF patients in our hospital.
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spelling pubmed-74160962020-08-14 Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study S., Noshadi M., Atarod A., Amouheidari F., Felfeliyan P., Shokrani J Biomed Phys Eng Original Article BACKGROUND: When using low-energy electron beams for the treatment of skin lesions, such as Mycosis Fungoides (MF), a beam spoiler is used to decrease electron therapeutic depth (R(90)) while increasing the surface dose. OBJECTIVE: The aim of this study was to evaluate the characteristics of a 5 MeV electron beam when using a spoiler for the local treatment of MF skin lesions by Monte Carlo (MC) simulation. MATERIAL AND METHODS: In this experimental study, a Siemens Primus treatment head and an acrylic spoiler, positioned at the end of applicator, were simulated using BEAMnrc, an EGSnrc user code. The modelled beam was validated by measurement using MP3-M water tank, Roos parallel plate chamber and Semi flex Chamber-31013 (all from PTW, Freiburg, Germany). For different spoiler thicknesses, dose distributions in water were calculated for 2 field sizes and were compared to those for the corresponding open fields. RESULTS: For a 1.3 cm spoiler, therapeutic range changed from 1.5 cm (open field) to 0.5 cm and 0.4 cm for 10 × 10 cm(2) and 20 × 20 cm(2) field sizes, respectively. Maximum increase in penumbra width was 2.8 and 3.8 cm for 10 × 10 cm(2) and 20 × 20 cm(2) field sizes, respectively. Maximum increase in bremsstrahlung contamination was %2 in both field sizes. CONCLUSION: R(90) decreased exponentially with increase in spoiler thickness. The effect of field size on penumbra was much larger for spoiled beam compared to the open beam. The results of this research can be applied to optimize the radiation treatment of MF patients in our hospital. Shiraz University of Medical Sciences 2020-08-01 /pmc/articles/PMC7416096/ /pubmed/32802792 http://dx.doi.org/10.31661/jbpe.v0i0.712 Text en Copyright: © Journal of Biomedical Physics and Engineering http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 Unported License, ( http://creativecommons.org/licenses/by-nc/4.0/ ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
S., Noshadi
M., Atarod
A., Amouheidari
F., Felfeliyan
P., Shokrani
Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study
title Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study
title_full Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study
title_fullStr Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study
title_full_unstemmed Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study
title_short Evaluation of Therapeutic Properties of a Low Energy Electron Beam Plus Spoiler for Local Treatment of Mycosis Fungoides: A Monte Carlo Study
title_sort evaluation of therapeutic properties of a low energy electron beam plus spoiler for local treatment of mycosis fungoides: a monte carlo study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416096/
https://www.ncbi.nlm.nih.gov/pubmed/32802792
http://dx.doi.org/10.31661/jbpe.v0i0.712
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