Cargando…

Glutamine uptake and utilization of human mesenchymal glioblastoma in orthotopic mouse model

BACKGROUND: Glioblastoma (GBM) are highly heterogeneous on the cellular and molecular basis. It has been proposed that glutamine metabolism of primary cells established from human tumors discriminates aggressive mesenchymal GBM subtype to other subtypes. METHODS: To study glutamine metabolism in viv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oizel, Kristell, Yang, Chendong, Renoult, Ophelie, Gautier, Fabien, Do, Quyen N., Joalland, Noemie, Gao, Xiaofei, Ko, Bookyung, Vallette, François, Ge, Woo-Ping, Paris, François, DeBerardinis, Ralph J., Pecqueur, Claire
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416393/ https://www.ncbi.nlm.nih.gov/pubmed/32789014 http://dx.doi.org/10.1186/s40170-020-00215-8

Ejemplares similares

Radiation-induced PGE(2) sustains human glioma cell growth and survival through EGF signaling
por: Brocard, Emeline, et al.
Publicado: (2015)

Targeting Metabolism to Induce Cell Death in Cancer Cells and Cancer Stem Cells
por: Pecqueur, Claire, et al.
Publicado: (2013)

Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma
por: Alzial, Gabriel, et al.
Publicado: (2021)

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target
por: Garnier, Delphine, et al.
Publicado: (2019)

The antitumor activity of human Vγ9Vδ2 T cells is impaired by TGF-β through significant phenotype, transcriptomic and metabolic changes
por: Rafia, Chirine, et al.
Publicado: (2023)

D-2-Hydroxyglutarate does not mimic all the IDH mutation effects, in particular the reduced etoposide-triggered apoptosis mediated by an alteration in mitochondrial NADH
por: Oizel, K, et al.
Publicado: (2015)

Exploiting radiation immunostimulatory effects to improve glioblastoma outcome
por: Awada, Hala, et al.
Publicado: (2022)

Identification of a transient state during the acquisition of temozolomide resistance in glioblastoma
por: Rabé, Marion, et al.
Publicado: (2020)

UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling
por: Sancerni, Tiphaine, et al.
Publicado: (2022)

Metabolic Adjustments following Glutaminase Inhibition by CB-839 in Glioblastoma Cell Lines
por: De los Santos-Jiménez, Juan, et al.
Publicado: (2023)

In vivo isotope tracing reveals a requirement for the electron transport chain in glucose and glutamine metabolism by tumors
por: Pachnis, Panayotis, et al.
Publicado: (2022)

Lkb1 deficiency confers glutamine dependency in polycystic kidney disease
por: Flowers, Ebony M., et al.
Publicado: (2018)

TOM20-mediated transfer of Bcl2 from ER to MAM and mitochondria upon induction of apoptosis
por: Lalier, Lisenn, et al.
Publicado: (2021)

Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction
por: Cetinbas, Naniye, et al.
Publicado: (2014)

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine
por: Cetinbas, Naniye Mallı, et al.
Publicado: (2016)

Drug Resistance in Glioblastoma: The Two Faces of Oxidative Stress
por: Olivier, Christophe, et al.
Publicado: (2021)

Targeting and killing glioblastoma with monoclonal antibody to O-acetyl GD2 ganglioside
por: Fleurence, Julien, et al.
Publicado: (2016)

Drug resistance in glioblastoma: are persisters the key to therapy?
por: Oliver, Lisa, et al.
Publicado: (2020)

ABT-737 and/or folate reverse the PDGF-induced alterations in the mitochondrial apoptotic pathway in low-grade glioma patients
por: Debien, Emilie, et al.
Publicado: (2011)

Emerging Challenges of Preclinical Models of Anti-tumor Immunotherapeutic Strategies Utilizing Vγ9Vδ2 T Cells
por: Joalland, Noémie, et al.
Publicado: (2020)

Loss of a Negative Regulator of mTORC1 Induces Aerobic Glycolysis and Altered Fiber Composition in Skeletal Muscle
por: Dutchak, Paul A., et al.
Publicado: (2018)

Glutamine Synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma
por: Tardito, Saverio, et al.
Publicado: (2015)

An Orthotopic Model of Glioblastoma Is Resistant to Radiodynamic Therapy with 5-AminoLevulinic Acid
por: Dupin, Charles, et al.
Publicado: (2022)

Metabolic heterogeneity in cancer
por: DeBerardinis, Ralph J
Publicado: (2014)

Q&A: Targeting metabolism to diagnose and treat cancer
por: DeBerardinis, Ralph J
Publicado: (2014)

Opposite role of Bax and BCL-2 in the anti-tumoral responses of the immune system
por: Bougras, Gwenola, et al.
Publicado: (2004)

Pyruvate dehydrogenase activity is required for optimal growth under lipid deficient conditions
por: Rajagopalan, Kartik, et al.
Publicado: (2014)

Postoperative resveratrol administration improves prognosis of rat orthotopic glioblastomas
por: Song, Xue, et al.
Publicado: (2018)

Orthotopic Glioblastoma Models for Evaluation of the Clinical Target Volume Concept
por: Bütof, Rebecca, et al.
Publicado: (2022)

Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone
por: Chakrabarti, Gaurab, et al.
Publicado: (2015)

FSMP-02. CHANGES IN GLUTAMINE METABOLISM INDUCED BY OXALOACETATE IN GLIOBLASTOMA
por: Ijare, Omkar, et al.
Publicado: (2021)

The Activation of Mesenchymal Stem Cells by Glioblastoma Microvesicles Alters Their Exosomal Secretion of miR-100-5p, miR-9-5p and let-7d-5p
por: Garnier, Delphine, et al.
Publicado: (2022)

Locoregional Confinement and Major Clinical Benefit of (188)Re-Loaded CXCR4-Targeted Nanocarriers in an Orthotopic Human to Mouse Model of Glioblastoma
por: Séhédic, Delphine, et al.
Publicado: (2017)

Fundamentals of cancer metabolism
por: DeBerardinis, Ralph J., et al.
Publicado: (2016)

In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
por: Kaushik, Akash K., et al.
Publicado: (2022)

miR-370-3p Is a Therapeutic Tool in Anti-glioblastoma Therapy but Is Not an Intratumoral or Cell-free Circulating Biomarker
por: Nadaradjane, Arulraj, et al.
Publicado: (2018)

Targeting glutamine uptake in AML
por: Jacque, Nathalie, et al.
Publicado: (2014)

24th “Nantes Actualités en Transplantation” and 4th “LabEx Immunotherapy-Graft-Oncology” NAT and IGO Joint Meeting “New Horizons in Immunotherapy”
por: Joalland, Noémie, et al.
Publicado: (2021)

Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine–Glutamate Cycle
por: Gandasi, Nikhil R., et al.
Publicado: (2021)

Radiosensitization of orthotopic GIC-driven glioblastoma by doxycycline causes skin damage
por: Frosina, Guido, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_99877qho8gb7ndsahhc468q2ck