Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?

The outbreak of coronavirus disease 2019 (COVID-19) has posed a severe threat to global health management system since it has been detected in the human body. This pandemic was prompted by severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and rapidly developed into a public emergency wi...

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Autores principales: Tao, Huaqiang, Bai, Jiaxiang, Zhang, Weicheng, Zheng, Kai, Guan, Pengfei, Ge, Gaoran, Li, Meng, Geng, Dechun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416709/
https://www.ncbi.nlm.nih.gov/pubmed/33254500
http://dx.doi.org/10.1016/j.mehy.2020.110178
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author Tao, Huaqiang
Bai, Jiaxiang
Zhang, Weicheng
Zheng, Kai
Guan, Pengfei
Ge, Gaoran
Li, Meng
Geng, Dechun
author_facet Tao, Huaqiang
Bai, Jiaxiang
Zhang, Weicheng
Zheng, Kai
Guan, Pengfei
Ge, Gaoran
Li, Meng
Geng, Dechun
author_sort Tao, Huaqiang
collection PubMed
description The outbreak of coronavirus disease 2019 (COVID-19) has posed a severe threat to global health management system since it has been detected in the human body. This pandemic was prompted by severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and rapidly developed into a public emergency with an alarming increase in cases and deaths. The increasing explorations to SARS-CoV-2 infection guide us to consider whether bone lesion is followed by this pathologic process. We especially focus on the underlying pathobiology that SARS-CoV-2 possibly mediated in bone remodeling and analyze the association of bone destruction with ACE2 in COVID-19 incidence, for preferable understanding the pathogenesis and providing necessary clinical management in orthopedics.
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spelling pubmed-74167092020-08-10 Bone biology and COVID-19 infection: Is ACE2 a potential influence factor? Tao, Huaqiang Bai, Jiaxiang Zhang, Weicheng Zheng, Kai Guan, Pengfei Ge, Gaoran Li, Meng Geng, Dechun Med Hypotheses Article The outbreak of coronavirus disease 2019 (COVID-19) has posed a severe threat to global health management system since it has been detected in the human body. This pandemic was prompted by severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and rapidly developed into a public emergency with an alarming increase in cases and deaths. The increasing explorations to SARS-CoV-2 infection guide us to consider whether bone lesion is followed by this pathologic process. We especially focus on the underlying pathobiology that SARS-CoV-2 possibly mediated in bone remodeling and analyze the association of bone destruction with ACE2 in COVID-19 incidence, for preferable understanding the pathogenesis and providing necessary clinical management in orthopedics. Elsevier Ltd. 2020-11 2020-08-10 /pmc/articles/PMC7416709/ /pubmed/33254500 http://dx.doi.org/10.1016/j.mehy.2020.110178 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tao, Huaqiang
Bai, Jiaxiang
Zhang, Weicheng
Zheng, Kai
Guan, Pengfei
Ge, Gaoran
Li, Meng
Geng, Dechun
Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?
title Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?
title_full Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?
title_fullStr Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?
title_full_unstemmed Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?
title_short Bone biology and COVID-19 infection: Is ACE2 a potential influence factor?
title_sort bone biology and covid-19 infection: is ace2 a potential influence factor?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416709/
https://www.ncbi.nlm.nih.gov/pubmed/33254500
http://dx.doi.org/10.1016/j.mehy.2020.110178
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