High antibody titres induced by protein subunit vaccines using Mycobacterium ulcerans antigens Hsp18 and MUL_3720 with a TLR-2 agonist fail to protect against Buruli ulcer in mice

BACKGROUND: Mycobacterium ulcerans is the causative agent of a debilitating skin and soft tissue infection known as Buruli ulcer (BU). There is no vaccine against BU. The purpose of this study was to investigate the vaccine potential of two previously described immunogenic M. ulcerans proteins, MUL_...

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Detalles Bibliográficos
Autores principales: Mangas, Kirstie M., Tobias, Nicholas J., Marion, Estelle, Babonneau, Jérémie, Marsollier, Laurent, Porter, Jessica L., Pidot, Sacha J., Wong, Chinn Yi, Jackson, David C., Chua, Brendon Y., Stinear, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416718/
https://www.ncbi.nlm.nih.gov/pubmed/32844063
http://dx.doi.org/10.7717/peerj.9659

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