Host Polymorphisms May Impact SARS-CoV-2 Infectivity

Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its interna...

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Detalles Bibliográficos
Autores principales: Brest, Patrick, Refae, Sadal, Mograbi, Baharia, Hofman, Paul, Milano, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2020
Materias:
Forum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416730/
https://www.ncbi.nlm.nih.gov/pubmed/32828550
http://dx.doi.org/10.1016/j.tig.2020.08.003
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author Brest, Patrick
Refae, Sadal
Mograbi, Baharia
Hofman, Paul
Milano, Gerard
author_facet Brest, Patrick
Refae, Sadal
Mograbi, Baharia
Hofman, Paul
Milano, Gerard
author_sort Brest, Patrick
collection PubMed
description Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.
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spelling pubmed-74167302020-08-10 Host Polymorphisms May Impact SARS-CoV-2 Infectivity Brest, Patrick Refae, Sadal Mograbi, Baharia Hofman, Paul Milano, Gerard Trends Genet Forum Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected. The Authors. Published by Elsevier Ltd. 2020-11 2020-08-10 /pmc/articles/PMC7416730/ /pubmed/32828550 http://dx.doi.org/10.1016/j.tig.2020.08.003 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Forum
Brest, Patrick
Refae, Sadal
Mograbi, Baharia
Hofman, Paul
Milano, Gerard
Host Polymorphisms May Impact SARS-CoV-2 Infectivity
title Host Polymorphisms May Impact SARS-CoV-2 Infectivity
title_full Host Polymorphisms May Impact SARS-CoV-2 Infectivity
title_fullStr Host Polymorphisms May Impact SARS-CoV-2 Infectivity
title_full_unstemmed Host Polymorphisms May Impact SARS-CoV-2 Infectivity
title_short Host Polymorphisms May Impact SARS-CoV-2 Infectivity
title_sort host polymorphisms may impact sars-cov-2 infectivity
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416730/
https://www.ncbi.nlm.nih.gov/pubmed/32828550
http://dx.doi.org/10.1016/j.tig.2020.08.003
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