Assessment of Four Scatter Correction Methods in In-111 SPECT Imaging: A Simulation Study

INTRODUCTION: Detection of compton scattered photons is one of the most important factors affecting the quality of single-photon emission computed tomography (SPECT) images. In most cases, the multiple-energy window acquisition methods are used for estimation of the scatter contribution into the main energy window(s) used in imaging. AIMS AND OBJECTIVES: The purpose of this study is to evaluate and compare the performance of four different scatter correction methods in In-111 SPECT imaging. Due to the lack of sufficient studies in this field, it can be useful to perform a more detailed and comparative study. MATERIALS AND METHODS: Four approximations for scatter correction of In-111 SPECT images are evaluated by using the Monte Carlo simulation. These methods are firstly applied on each of photopeak windows, separately. Then, the effect of the correction methods is investigated by considering both the photopeak windows. The images obtained from a simulated multiple-spheres phantom are used for the evaluation of the correction methods by using three assessment criteria, including the image contrast, relative noise, and the recovery coefficient. RESULTS: The results of this study show that the correction methods, when using the single photopeak windows, result in increase in image contrast with a significant level of noise. In return, when both the photopeak energy windows are used for imaging, it is possible to achieve the better image characteristics. CONCLUSION: The use of the proposed correction methods, by considering both the photopeak windows, leads to improve the image contrast with a reasonable level of image noise.