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Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts
Sickle cell disease (SCD) impacts liver and kidney function as well as skin integrity. These complications, as well as the hyperinflammatory state of SCD, could affect serum albumin. Serum albumin has key roles in antioxidant, anti-inflammatory and antithrombotic pathways and maintains vascular inte...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416942/ https://www.ncbi.nlm.nih.gov/pubmed/32776978 http://dx.doi.org/10.1371/journal.pone.0237543 |
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author | Nouraie, Mehdi Ashley-Koch, Allison E. Garrett, Melanie E. Sritharan, Nithya Zhang, Yingze Little, Jane Gordeuk, Victor R. Gladwin, Mark T. Telen, Marilyn J. Kato, Gregory J. |
author_facet | Nouraie, Mehdi Ashley-Koch, Allison E. Garrett, Melanie E. Sritharan, Nithya Zhang, Yingze Little, Jane Gordeuk, Victor R. Gladwin, Mark T. Telen, Marilyn J. Kato, Gregory J. |
author_sort | Nouraie, Mehdi |
collection | PubMed |
description | Sickle cell disease (SCD) impacts liver and kidney function as well as skin integrity. These complications, as well as the hyperinflammatory state of SCD, could affect serum albumin. Serum albumin has key roles in antioxidant, anti-inflammatory and antithrombotic pathways and maintains vascular integrity. In SCD, these pathways modulate disease severity and clinical outcomes. We used three independent SCD adult cohorts to assess clinical predictors of serum albumin as well its association with mortality. In 2553 SCD adult participants, the frequency of low (<35 g/L) serum albumin was 5%. Older age and lower hemoglobin (P <0.001) were associated with lower serum albumin in all three cohorts. In age and hemoglobin adjusted analysis, higher liver enzymes (P <0.05) were associated with lower serum albumin. In two of the three cohorts, lower kidney function as measured by Glomerular Filtration Rate (P<0.001) was associated with lower serum albumin. Lower serum albumin predicted higher risk of tricuspid regurgitation velocity ≥ 2.5 m/s (OR = 1.1 per g/L, P ≤0.01). In all three cohorts, patients with low serum albumin had higher mortality (adjusted HR ≥2.9, P ≤0.003). This study confirms the role of serum albumin as a biomarker of disease severity and prognosis in patients with SCD. Albumin as a biomarker and possible mediator of SCD severity should be studied further. |
format | Online Article Text |
id | pubmed-7416942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74169422020-08-19 Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts Nouraie, Mehdi Ashley-Koch, Allison E. Garrett, Melanie E. Sritharan, Nithya Zhang, Yingze Little, Jane Gordeuk, Victor R. Gladwin, Mark T. Telen, Marilyn J. Kato, Gregory J. PLoS One Research Article Sickle cell disease (SCD) impacts liver and kidney function as well as skin integrity. These complications, as well as the hyperinflammatory state of SCD, could affect serum albumin. Serum albumin has key roles in antioxidant, anti-inflammatory and antithrombotic pathways and maintains vascular integrity. In SCD, these pathways modulate disease severity and clinical outcomes. We used three independent SCD adult cohorts to assess clinical predictors of serum albumin as well its association with mortality. In 2553 SCD adult participants, the frequency of low (<35 g/L) serum albumin was 5%. Older age and lower hemoglobin (P <0.001) were associated with lower serum albumin in all three cohorts. In age and hemoglobin adjusted analysis, higher liver enzymes (P <0.05) were associated with lower serum albumin. In two of the three cohorts, lower kidney function as measured by Glomerular Filtration Rate (P<0.001) was associated with lower serum albumin. Lower serum albumin predicted higher risk of tricuspid regurgitation velocity ≥ 2.5 m/s (OR = 1.1 per g/L, P ≤0.01). In all three cohorts, patients with low serum albumin had higher mortality (adjusted HR ≥2.9, P ≤0.003). This study confirms the role of serum albumin as a biomarker of disease severity and prognosis in patients with SCD. Albumin as a biomarker and possible mediator of SCD severity should be studied further. Public Library of Science 2020-08-10 /pmc/articles/PMC7416942/ /pubmed/32776978 http://dx.doi.org/10.1371/journal.pone.0237543 Text en © 2020 Nouraie et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nouraie, Mehdi Ashley-Koch, Allison E. Garrett, Melanie E. Sritharan, Nithya Zhang, Yingze Little, Jane Gordeuk, Victor R. Gladwin, Mark T. Telen, Marilyn J. Kato, Gregory J. Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts |
title | Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts |
title_full | Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts |
title_fullStr | Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts |
title_full_unstemmed | Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts |
title_short | Serum albumin is independently associated with higher mortality in adult sickle cell patients: Results of three independent cohorts |
title_sort | serum albumin is independently associated with higher mortality in adult sickle cell patients: results of three independent cohorts |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416942/ https://www.ncbi.nlm.nih.gov/pubmed/32776978 http://dx.doi.org/10.1371/journal.pone.0237543 |
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