A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection

Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the...

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Autores principales: Cruces, Pablo, Retamal, Jaime, Hurtado, Daniel E., Erranz, Benjamín, Iturrieta, Pablo, González, Carlos, Díaz, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416996/
https://www.ncbi.nlm.nih.gov/pubmed/32778136
http://dx.doi.org/10.1186/s13054-020-03197-7
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author Cruces, Pablo
Retamal, Jaime
Hurtado, Daniel E.
Erranz, Benjamín
Iturrieta, Pablo
González, Carlos
Díaz, Franco
author_facet Cruces, Pablo
Retamal, Jaime
Hurtado, Daniel E.
Erranz, Benjamín
Iturrieta, Pablo
González, Carlos
Díaz, Franco
author_sort Cruces, Pablo
collection PubMed
description Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
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spelling pubmed-74169962020-08-11 A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection Cruces, Pablo Retamal, Jaime Hurtado, Daniel E. Erranz, Benjamín Iturrieta, Pablo González, Carlos Díaz, Franco Crit Care Review Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view. BioMed Central 2020-08-10 /pmc/articles/PMC7416996/ /pubmed/32778136 http://dx.doi.org/10.1186/s13054-020-03197-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Cruces, Pablo
Retamal, Jaime
Hurtado, Daniel E.
Erranz, Benjamín
Iturrieta, Pablo
González, Carlos
Díaz, Franco
A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
title A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
title_full A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
title_fullStr A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
title_full_unstemmed A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
title_short A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
title_sort physiological approach to understand the role of respiratory effort in the progression of lung injury in sars-cov-2 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416996/
https://www.ncbi.nlm.nih.gov/pubmed/32778136
http://dx.doi.org/10.1186/s13054-020-03197-7
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