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Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes

Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a well-characterised GDM prospective cohort of 1035 women following up to 8 years postpartum. Lipidomics profiling coveri...

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Autores principales: Lai, Mi, Al Rijjal, Dana, Röst, Hannes L, Dai, Feihan F, Gunderson, Erica P, Wheeler, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417169/
https://www.ncbi.nlm.nih.gov/pubmed/32748787
http://dx.doi.org/10.7554/eLife.59153
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author Lai, Mi
Al Rijjal, Dana
Röst, Hannes L
Dai, Feihan F
Gunderson, Erica P
Wheeler, Michael B
author_facet Lai, Mi
Al Rijjal, Dana
Röst, Hannes L
Dai, Feihan F
Gunderson, Erica P
Wheeler, Michael B
author_sort Lai, Mi
collection PubMed
description Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a well-characterised GDM prospective cohort of 1035 women following up to 8 years postpartum. Lipidomics profiling covering >1000 lipids was performed on fasting plasma samples from participants 6–9 week postpartum (171 incident T2D vs. 179 controls). We discovered 311 lipids positively and 70 lipids negatively associated with T2D risk. The upregulation of glycerolipid metabolism involving triacylglycerol and diacylglycerol biosynthesis suggested activated lipid storage before diabetes onset. In contrast, decreased sphingomyelines, hexosylceramide and lactosylceramide indicated impaired sphingolipid metabolism. Additionally, a lipid signature was identified to effectively predict future diabetes risk. These findings demonstrate an underlying dyslipidemia during the early postpartum in those GDM women who progress to T2D and suggest endogenous lipogenesis may be a driving force for future diabetes onset.
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spelling pubmed-74171692020-08-12 Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes Lai, Mi Al Rijjal, Dana Röst, Hannes L Dai, Feihan F Gunderson, Erica P Wheeler, Michael B eLife Human Biology and Medicine Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a well-characterised GDM prospective cohort of 1035 women following up to 8 years postpartum. Lipidomics profiling covering >1000 lipids was performed on fasting plasma samples from participants 6–9 week postpartum (171 incident T2D vs. 179 controls). We discovered 311 lipids positively and 70 lipids negatively associated with T2D risk. The upregulation of glycerolipid metabolism involving triacylglycerol and diacylglycerol biosynthesis suggested activated lipid storage before diabetes onset. In contrast, decreased sphingomyelines, hexosylceramide and lactosylceramide indicated impaired sphingolipid metabolism. Additionally, a lipid signature was identified to effectively predict future diabetes risk. These findings demonstrate an underlying dyslipidemia during the early postpartum in those GDM women who progress to T2D and suggest endogenous lipogenesis may be a driving force for future diabetes onset. eLife Sciences Publications, Ltd 2020-08-04 /pmc/articles/PMC7417169/ /pubmed/32748787 http://dx.doi.org/10.7554/eLife.59153 Text en © 2020, Lai et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Human Biology and Medicine
Lai, Mi
Al Rijjal, Dana
Röst, Hannes L
Dai, Feihan F
Gunderson, Erica P
Wheeler, Michael B
Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
title Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
title_full Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
title_fullStr Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
title_full_unstemmed Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
title_short Underlying dyslipidemia postpartum in women with a recent GDM pregnancy who develop type 2 diabetes
title_sort underlying dyslipidemia postpartum in women with a recent gdm pregnancy who develop type 2 diabetes
topic Human Biology and Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417169/
https://www.ncbi.nlm.nih.gov/pubmed/32748787
http://dx.doi.org/10.7554/eLife.59153
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