Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection

Novel 2019 coronavirus (COVID-19) infection usually causes a respiratory disease that may vary in severity from mild symptoms to severe pneumonia with multiple organ failure. Coagulation abnormalities are frequent, and reports suggest that COVID-19 may predispose to venous and arterial thrombotic co...

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Autores principales: Mietto, Cristina, Salice, Valentina, Ferraris, Matteo, Zuccon, Gianmarco, Valdambrini, Federico, Piazzalunga, Giorgio, Socrate, Anna Maria, Radrizzani, Danilo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Covid-19
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417264/
https://www.ncbi.nlm.nih.gov/pubmed/32791191
http://dx.doi.org/10.1016/j.avsg.2020.08.004
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author Mietto, Cristina
Salice, Valentina
Ferraris, Matteo
Zuccon, Gianmarco
Valdambrini, Federico
Piazzalunga, Giorgio
Socrate, Anna Maria
Radrizzani, Danilo
author_facet Mietto, Cristina
Salice, Valentina
Ferraris, Matteo
Zuccon, Gianmarco
Valdambrini, Federico
Piazzalunga, Giorgio
Socrate, Anna Maria
Radrizzani, Danilo
author_sort Mietto, Cristina
collection PubMed
description Novel 2019 coronavirus (COVID-19) infection usually causes a respiratory disease that may vary in severity from mild symptoms to severe pneumonia with multiple organ failure. Coagulation abnormalities are frequent, and reports suggest that COVID-19 may predispose to venous and arterial thrombotic complications. We report a case of acute lower limb ischemia and resistance to heparin as the onset of COVID-19 disease, preceding the development of respiratory failure. This case highlights that the shift of coagulation profile toward hypercoagulability was associated with the acute ischemic event and influenced the therapy.
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spelling pubmed-74172642020-08-11 Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection Mietto, Cristina Salice, Valentina Ferraris, Matteo Zuccon, Gianmarco Valdambrini, Federico Piazzalunga, Giorgio Socrate, Anna Maria Radrizzani, Danilo Ann Vasc Surg Covid-19 Novel 2019 coronavirus (COVID-19) infection usually causes a respiratory disease that may vary in severity from mild symptoms to severe pneumonia with multiple organ failure. Coagulation abnormalities are frequent, and reports suggest that COVID-19 may predispose to venous and arterial thrombotic complications. We report a case of acute lower limb ischemia and resistance to heparin as the onset of COVID-19 disease, preceding the development of respiratory failure. This case highlights that the shift of coagulation profile toward hypercoagulability was associated with the acute ischemic event and influenced the therapy. Elsevier Inc. 2020-11 2020-08-11 /pmc/articles/PMC7417264/ /pubmed/32791191 http://dx.doi.org/10.1016/j.avsg.2020.08.004 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Covid-19
Mietto, Cristina
Salice, Valentina
Ferraris, Matteo
Zuccon, Gianmarco
Valdambrini, Federico
Piazzalunga, Giorgio
Socrate, Anna Maria
Radrizzani, Danilo
Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection
title Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection
title_full Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection
title_fullStr Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection
title_full_unstemmed Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection
title_short Acute Lower Limb Ischemia as Clinical Presentation of COVID-19 Infection
title_sort acute lower limb ischemia as clinical presentation of covid-19 infection
topic Covid-19
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417264/
https://www.ncbi.nlm.nih.gov/pubmed/32791191
http://dx.doi.org/10.1016/j.avsg.2020.08.004
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