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Mitochondrial DNA control region variation in a population sample from Thailand

Mitochondrial DNA (mtDNA) control region sequences from hair samples of 213 individuals from Thailand were analyzed using Sanger sequencing. A total of 170 different haplotypes were identified, of which 146 occurred only once (unique haplotypes). The dataset showed a random match probability of 0.87...

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Autores principales: Sauer, Dirk Christopher, Naue, Jana, Immel, Uta-Dorothee, Lutz-Bonengel, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417404/
https://www.ncbi.nlm.nih.gov/pubmed/32358724
http://dx.doi.org/10.1007/s00414-020-02303-2
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author Sauer, Dirk Christopher
Naue, Jana
Immel, Uta-Dorothee
Lutz-Bonengel, Sabine
author_facet Sauer, Dirk Christopher
Naue, Jana
Immel, Uta-Dorothee
Lutz-Bonengel, Sabine
author_sort Sauer, Dirk Christopher
collection PubMed
description Mitochondrial DNA (mtDNA) control region sequences from hair samples of 213 individuals from Thailand were analyzed using Sanger sequencing. A total of 170 different haplotypes were identified, of which 146 occurred only once (unique haplotypes). The dataset showed a random match probability of 0.87% and a haplotype diversity of 0.9960. The samples were assigned to 85 different haplogroups with B5a, F1a1a, and M being the most frequent ones. Pairwise F(ST)-values between this and other Southeast and East Asian populations revealed significant but relatively low differences, indicating a close relation. Heteroplasmic positions were observed in 12.2% of hair samples confirming the frequent appearance of heteroplasmic positions in hairs. This dataset will complement existing data as an mtDNA reference for forensic investigations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00414-020-02303-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-74174042020-08-17 Mitochondrial DNA control region variation in a population sample from Thailand Sauer, Dirk Christopher Naue, Jana Immel, Uta-Dorothee Lutz-Bonengel, Sabine Int J Legal Med Original Article Mitochondrial DNA (mtDNA) control region sequences from hair samples of 213 individuals from Thailand were analyzed using Sanger sequencing. A total of 170 different haplotypes were identified, of which 146 occurred only once (unique haplotypes). The dataset showed a random match probability of 0.87% and a haplotype diversity of 0.9960. The samples were assigned to 85 different haplogroups with B5a, F1a1a, and M being the most frequent ones. Pairwise F(ST)-values between this and other Southeast and East Asian populations revealed significant but relatively low differences, indicating a close relation. Heteroplasmic positions were observed in 12.2% of hair samples confirming the frequent appearance of heteroplasmic positions in hairs. This dataset will complement existing data as an mtDNA reference for forensic investigations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00414-020-02303-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-05-01 2020 /pmc/articles/PMC7417404/ /pubmed/32358724 http://dx.doi.org/10.1007/s00414-020-02303-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Original Article
Sauer, Dirk Christopher
Naue, Jana
Immel, Uta-Dorothee
Lutz-Bonengel, Sabine
Mitochondrial DNA control region variation in a population sample from Thailand
title Mitochondrial DNA control region variation in a population sample from Thailand
title_full Mitochondrial DNA control region variation in a population sample from Thailand
title_fullStr Mitochondrial DNA control region variation in a population sample from Thailand
title_full_unstemmed Mitochondrial DNA control region variation in a population sample from Thailand
title_short Mitochondrial DNA control region variation in a population sample from Thailand
title_sort mitochondrial dna control region variation in a population sample from thailand
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417404/
https://www.ncbi.nlm.nih.gov/pubmed/32358724
http://dx.doi.org/10.1007/s00414-020-02303-2
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