Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations

Recent advances in chronic lymphocytic leukemia (CLL) includes description of disease genomic landscape, inclusion of prognostic relevant genetic tests in CLL workflow and evaluation of minimal residual disease (MRD)(1) in parallel with the increase availability of novel therapy agents. In this revi...

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Detalles Bibliográficos
Autores principales: Zalcberg, Ilana, D’Andrea, Mariana Gamma, Monteiro, Lucia, Pimenta, Glicínia, Xisto, Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Hematologia e Hemoterapia 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417454/
https://www.ncbi.nlm.nih.gov/pubmed/31784406
http://dx.doi.org/10.1016/j.htct.2019.07.006
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author Zalcberg, Ilana
D’Andrea, Mariana Gamma
Monteiro, Lucia
Pimenta, Glicínia
Xisto, Beth
author_facet Zalcberg, Ilana
D’Andrea, Mariana Gamma
Monteiro, Lucia
Pimenta, Glicínia
Xisto, Beth
author_sort Zalcberg, Ilana
collection PubMed
description Recent advances in chronic lymphocytic leukemia (CLL) includes description of disease genomic landscape, inclusion of prognostic relevant genetic tests in CLL workflow and evaluation of minimal residual disease (MRD)(1) in parallel with the increase availability of novel therapy agents. In this review, the theoretical and practical aspects of response assessment have been discussed. These are based on updated recommendations of the European Research Initiative on Chronic Lymphocytic Leukemia (ERIC) for genetic tests (TP53 mutation and IGHV status) and flow cytometry analysis for CLL. Methodological approaches and interpretation of results were also discussed.(2,3)
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spelling pubmed-74174542020-08-14 Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations Zalcberg, Ilana D’Andrea, Mariana Gamma Monteiro, Lucia Pimenta, Glicínia Xisto, Beth Hematol Transfus Cell Ther Review Article Recent advances in chronic lymphocytic leukemia (CLL) includes description of disease genomic landscape, inclusion of prognostic relevant genetic tests in CLL workflow and evaluation of minimal residual disease (MRD)(1) in parallel with the increase availability of novel therapy agents. In this review, the theoretical and practical aspects of response assessment have been discussed. These are based on updated recommendations of the European Research Initiative on Chronic Lymphocytic Leukemia (ERIC) for genetic tests (TP53 mutation and IGHV status) and flow cytometry analysis for CLL. Methodological approaches and interpretation of results were also discussed.(2,3) Sociedade Brasileira de Hematologia e Hemoterapia 2020 2019-09-11 /pmc/articles/PMC7417454/ /pubmed/31784406 http://dx.doi.org/10.1016/j.htct.2019.07.006 Text en © 2019 Published by Elsevier Editora Ltda. on behalf of Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Zalcberg, Ilana
D’Andrea, Mariana Gamma
Monteiro, Lucia
Pimenta, Glicínia
Xisto, Beth
Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations
title Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations
title_full Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations
title_fullStr Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations
title_full_unstemmed Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations
title_short Multidisciplinary diagnostics of chronic lymphocytic leukemia: European Research Initiative on CLL - ERIC recommendations
title_sort multidisciplinary diagnostics of chronic lymphocytic leukemia: european research initiative on cll - eric recommendations
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417454/
https://www.ncbi.nlm.nih.gov/pubmed/31784406
http://dx.doi.org/10.1016/j.htct.2019.07.006
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