Cargando…
Insights Into Dynamics of Inhibitor and Ubiquitin-Like Protein Binding in SARS-CoV-2 Papain-Like Protease
Covid-19 is caused by a novel form of coronavirus for which there are currently no vaccines or anti-viral drugs. This virus, termed SARS-CoV-2 (CoV2), contains Papain-like protease (PLpro) involved in viral replication and immune response evasion. Drugs targeting this protease therefore have great p...
Autores principales: | Bosken, Yuliana K., Cholko, Timothy, Lou, Yuan-Chao, Wu, Kuen-Phon, Chang, Chia-en A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417481/ https://www.ncbi.nlm.nih.gov/pubmed/32850963 http://dx.doi.org/10.3389/fmolb.2020.00174 |
Ejemplares similares
-
Computational study of the binding orientation and affinity of noncovalent inhibitors of the papain-like protease (PLpro) from SARS-CoV-1 considering the protein flexibility by using molecular dynamics and cross-docking
por: Castillo-Campos, Luis, et al.
Publicado: (2023) -
Substitution of a Surface-Exposed Residue Involved in an Allosteric Network Enhances Tryptophan Synthase Function in Cells
por: D’Amico, Rebecca N., et al.
Publicado: (2021) -
Structural View and Substrate Specificity of Papain-like Protease from Avian Infectious Bronchitis Virus
por: Kong, Lingying, et al.
Publicado: (2015) -
Selectivity in ISG15 and ubiquitin recognition by the SARS coronavirus papain-like protease
por: Lindner, Holger A., et al.
Publicado: (2007) -
Monolithic Papain-Immobilized Enzyme Reactors for Automated Structural Characterization of Monoclonal Antibodies
por: Rinaldi, Francesca, et al.
Publicado: (2021)