Cargando…
Non-thermal effects of radiofrequency electromagnetic fields
We explored the non-thermal effects of radiofrequency (RF) electromagnetic fields and established a theoretical framework to elucidate their electrophysiological mechanisms. In experiments, we used a preclinical treatment device to treat the human colon cancer cell lines HT-29 and SW480 with either...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417565/ https://www.ncbi.nlm.nih.gov/pubmed/32778682 http://dx.doi.org/10.1038/s41598-020-69561-3 |
_version_ | 1783569522092933120 |
---|---|
author | Wust, Peter Kortüm, Benedikt Strauss, Ulf Nadobny, Jacek Zschaeck, Sebastian Beck, Marcus Stein, Ulrike Ghadjar, Pirus |
author_facet | Wust, Peter Kortüm, Benedikt Strauss, Ulf Nadobny, Jacek Zschaeck, Sebastian Beck, Marcus Stein, Ulrike Ghadjar, Pirus |
author_sort | Wust, Peter |
collection | PubMed |
description | We explored the non-thermal effects of radiofrequency (RF) electromagnetic fields and established a theoretical framework to elucidate their electrophysiological mechanisms. In experiments, we used a preclinical treatment device to treat the human colon cancer cell lines HT-29 and SW480 with either water bath heating (WB-HT) or 13.56 MHz RF hyperthermia (RF-HT) at 42 °C for 60 min and analyzed the proliferation and clonogenicity. We elaborated an electrical model for cell membranes and ion channels and estimated the resulting ion fluxes. The results showed that, for both cell lines, using RF-HT significantly reduced proliferation and clonogenicity compared to WB-HT. According to our model, the RF electric field component was rectified and smoothed in the direction of the channel, which resulted in a DC voltage of ~ 1 µV. This may induce ion fluxes that can potentially cause relevant disequilibrium of most ions. Therefore, RF-HT creates additional non-thermal effects in association with significant ion fluxes. Increasing the understanding of these effects can help improve cancer therapy. |
format | Online Article Text |
id | pubmed-7417565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74175652020-08-11 Non-thermal effects of radiofrequency electromagnetic fields Wust, Peter Kortüm, Benedikt Strauss, Ulf Nadobny, Jacek Zschaeck, Sebastian Beck, Marcus Stein, Ulrike Ghadjar, Pirus Sci Rep Article We explored the non-thermal effects of radiofrequency (RF) electromagnetic fields and established a theoretical framework to elucidate their electrophysiological mechanisms. In experiments, we used a preclinical treatment device to treat the human colon cancer cell lines HT-29 and SW480 with either water bath heating (WB-HT) or 13.56 MHz RF hyperthermia (RF-HT) at 42 °C for 60 min and analyzed the proliferation and clonogenicity. We elaborated an electrical model for cell membranes and ion channels and estimated the resulting ion fluxes. The results showed that, for both cell lines, using RF-HT significantly reduced proliferation and clonogenicity compared to WB-HT. According to our model, the RF electric field component was rectified and smoothed in the direction of the channel, which resulted in a DC voltage of ~ 1 µV. This may induce ion fluxes that can potentially cause relevant disequilibrium of most ions. Therefore, RF-HT creates additional non-thermal effects in association with significant ion fluxes. Increasing the understanding of these effects can help improve cancer therapy. Nature Publishing Group UK 2020-08-10 /pmc/articles/PMC7417565/ /pubmed/32778682 http://dx.doi.org/10.1038/s41598-020-69561-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wust, Peter Kortüm, Benedikt Strauss, Ulf Nadobny, Jacek Zschaeck, Sebastian Beck, Marcus Stein, Ulrike Ghadjar, Pirus Non-thermal effects of radiofrequency electromagnetic fields |
title | Non-thermal effects of radiofrequency electromagnetic fields |
title_full | Non-thermal effects of radiofrequency electromagnetic fields |
title_fullStr | Non-thermal effects of radiofrequency electromagnetic fields |
title_full_unstemmed | Non-thermal effects of radiofrequency electromagnetic fields |
title_short | Non-thermal effects of radiofrequency electromagnetic fields |
title_sort | non-thermal effects of radiofrequency electromagnetic fields |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417565/ https://www.ncbi.nlm.nih.gov/pubmed/32778682 http://dx.doi.org/10.1038/s41598-020-69561-3 |
work_keys_str_mv | AT wustpeter nonthermaleffectsofradiofrequencyelectromagneticfields AT kortumbenedikt nonthermaleffectsofradiofrequencyelectromagneticfields AT straussulf nonthermaleffectsofradiofrequencyelectromagneticfields AT nadobnyjacek nonthermaleffectsofradiofrequencyelectromagneticfields AT zschaecksebastian nonthermaleffectsofradiofrequencyelectromagneticfields AT beckmarcus nonthermaleffectsofradiofrequencyelectromagneticfields AT steinulrike nonthermaleffectsofradiofrequencyelectromagneticfields AT ghadjarpirus nonthermaleffectsofradiofrequencyelectromagneticfields |