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Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility
Titanium dioxide (TiO(2)) has a long history of application in blood contact materials, but it often suffers from insufficient anticoagulant properties. Recently, we have revealed the photocatalytic effect of TiO(2) also induces anticoagulant properties. However, for long-term vascular implant devic...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417617/ https://www.ncbi.nlm.nih.gov/pubmed/32817912 http://dx.doi.org/10.1016/j.bioactmat.2020.07.009 |
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author | Chen, Jiang Dai, Sheng Liu, Luying Maitz, Manfred F. Liao, Yuzhen Cui, Jiawei Zhao, Ansha Yang, Ping Huang, Nan Wang, Yunbing |
author_facet | Chen, Jiang Dai, Sheng Liu, Luying Maitz, Manfred F. Liao, Yuzhen Cui, Jiawei Zhao, Ansha Yang, Ping Huang, Nan Wang, Yunbing |
author_sort | Chen, Jiang |
collection | PubMed |
description | Titanium dioxide (TiO(2)) has a long history of application in blood contact materials, but it often suffers from insufficient anticoagulant properties. Recently, we have revealed the photocatalytic effect of TiO(2) also induces anticoagulant properties. However, for long-term vascular implant devices such as vascular stents, besides anticoagulation, also anti-inflammatory, anti-hyperplastic properties, and the ability to support endothelial repair, are desired. To meet these requirements, here, we immobilized silver nanoparticles (AgNPs) on the surface of TiO(2) nanotubes (TiO(2)-NTs) to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties. The photo-functionalized TiO(2)-NTs showed protein-fouling resistance, causing the anticoagulant property and the ability to suppress cell adhesion. The immobilized AgNPs increased the photocatalytic activity of TiO(2)-NTs to enhances its photo-induced anticoagulant property. The AgNP density was optimized to endow the TiO(2)-NTs with anti-inflammatory property, a strong inhibitory effect on smooth muscle cells (SMCs), and low toxicity to endothelial cells (ECs). The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO(2)-NTs and the multifunctional AgNPs, and therefore has enormous potential in the field of cardiovascular implant devices. Our research could be a useful reference for further designing of multifunctional TiO(2) materials with high vascular biocompatibility. |
format | Online Article Text |
id | pubmed-7417617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-74176172020-08-16 Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility Chen, Jiang Dai, Sheng Liu, Luying Maitz, Manfred F. Liao, Yuzhen Cui, Jiawei Zhao, Ansha Yang, Ping Huang, Nan Wang, Yunbing Bioact Mater Article Titanium dioxide (TiO(2)) has a long history of application in blood contact materials, but it often suffers from insufficient anticoagulant properties. Recently, we have revealed the photocatalytic effect of TiO(2) also induces anticoagulant properties. However, for long-term vascular implant devices such as vascular stents, besides anticoagulation, also anti-inflammatory, anti-hyperplastic properties, and the ability to support endothelial repair, are desired. To meet these requirements, here, we immobilized silver nanoparticles (AgNPs) on the surface of TiO(2) nanotubes (TiO(2)-NTs) to obtain a composite material with enhanced photo-induced anticoagulant property and improvement of the other requested properties. The photo-functionalized TiO(2)-NTs showed protein-fouling resistance, causing the anticoagulant property and the ability to suppress cell adhesion. The immobilized AgNPs increased the photocatalytic activity of TiO(2)-NTs to enhances its photo-induced anticoagulant property. The AgNP density was optimized to endow the TiO(2)-NTs with anti-inflammatory property, a strong inhibitory effect on smooth muscle cells (SMCs), and low toxicity to endothelial cells (ECs). The in vivo test indicated that the photofunctionalized composite material achieved outstanding biocompatibility in vasculature via the synergy of photo-functionalized TiO(2)-NTs and the multifunctional AgNPs, and therefore has enormous potential in the field of cardiovascular implant devices. Our research could be a useful reference for further designing of multifunctional TiO(2) materials with high vascular biocompatibility. KeAi Publishing 2020-08-08 /pmc/articles/PMC7417617/ /pubmed/32817912 http://dx.doi.org/10.1016/j.bioactmat.2020.07.009 Text en © 2020 [The Author/The Authors] https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Chen, Jiang Dai, Sheng Liu, Luying Maitz, Manfred F. Liao, Yuzhen Cui, Jiawei Zhao, Ansha Yang, Ping Huang, Nan Wang, Yunbing Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility |
title | Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility |
title_full | Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility |
title_fullStr | Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility |
title_full_unstemmed | Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility |
title_short | Photo-functionalized TiO(2) nanotubes decorated with multifunctional Ag nanoparticles for enhanced vascular biocompatibility |
title_sort | photo-functionalized tio(2) nanotubes decorated with multifunctional ag nanoparticles for enhanced vascular biocompatibility |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417617/ https://www.ncbi.nlm.nih.gov/pubmed/32817912 http://dx.doi.org/10.1016/j.bioactmat.2020.07.009 |
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