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Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy

BACKGROUND: Apathy is one of the most common non-motor symptoms of Parkinson’s disease (PD). However, its pathophysiology remains unclear. METHODS: We analyzed resting-state functional magnetic resonance imaging (MRI) data acquired at a 3.0T MRI scanner using the amplitude of low-frequency fluctuati...

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Autores principales: Sun, Hai-Hua, Hu, Jian-Bin, Chen, Jing, Wang, Xue-Yang, Wang, Xiao-Li, Pan, Ping-Lei, Liu, Chun-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417661/
https://www.ncbi.nlm.nih.gov/pubmed/32848582
http://dx.doi.org/10.3389/fnins.2020.00830
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author Sun, Hai-Hua
Hu, Jian-Bin
Chen, Jing
Wang, Xue-Yang
Wang, Xiao-Li
Pan, Ping-Lei
Liu, Chun-Feng
author_facet Sun, Hai-Hua
Hu, Jian-Bin
Chen, Jing
Wang, Xue-Yang
Wang, Xiao-Li
Pan, Ping-Lei
Liu, Chun-Feng
author_sort Sun, Hai-Hua
collection PubMed
description BACKGROUND: Apathy is one of the most common non-motor symptoms of Parkinson’s disease (PD). However, its pathophysiology remains unclear. METHODS: We analyzed resting-state functional magnetic resonance imaging (MRI) data acquired at a 3.0T MRI scanner using the amplitude of low-frequency fluctuation (ALFF) metric in 20 de novo, drug-naïve, non-demented PD patients with apathy (PD-A), 26 PD patients without apathy (PD-NA) without comorbidity of depressive or anxious symptoms, and 23 matched healthy control (HC) subjects. RESULTS: We found that the ALFF decreased significantly in the bilateral nucleus accumbens, dorsal anterior cingulate cortex (ACC), and left dorsolateral prefrontal cortex in patients with PD-A compared to patients with PD-NA and HC subjects. Furthermore, apathy severity was negatively correlated with the ALFF in the bilateral nucleus accumbens and dorsal ACC in the pooled patients with PD. CONCLUSION: The present study characterized the functional pattern of changes in spontaneous neural activity in patients with PD-A. With the aim to better elucidate the pathophysiological mechanisms responsible for these changes, this study controlled for the potentially confounding effects of dopaminergic medication, depression, anxiety, and global cognitive impairment. The findings of the current study add to the literature by highlighting potential abnormalities in mesocorticolimbic pathways involved in the development of apathy in PD.
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spelling pubmed-74176612020-08-25 Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy Sun, Hai-Hua Hu, Jian-Bin Chen, Jing Wang, Xue-Yang Wang, Xiao-Li Pan, Ping-Lei Liu, Chun-Feng Front Neurosci Neuroscience BACKGROUND: Apathy is one of the most common non-motor symptoms of Parkinson’s disease (PD). However, its pathophysiology remains unclear. METHODS: We analyzed resting-state functional magnetic resonance imaging (MRI) data acquired at a 3.0T MRI scanner using the amplitude of low-frequency fluctuation (ALFF) metric in 20 de novo, drug-naïve, non-demented PD patients with apathy (PD-A), 26 PD patients without apathy (PD-NA) without comorbidity of depressive or anxious symptoms, and 23 matched healthy control (HC) subjects. RESULTS: We found that the ALFF decreased significantly in the bilateral nucleus accumbens, dorsal anterior cingulate cortex (ACC), and left dorsolateral prefrontal cortex in patients with PD-A compared to patients with PD-NA and HC subjects. Furthermore, apathy severity was negatively correlated with the ALFF in the bilateral nucleus accumbens and dorsal ACC in the pooled patients with PD. CONCLUSION: The present study characterized the functional pattern of changes in spontaneous neural activity in patients with PD-A. With the aim to better elucidate the pathophysiological mechanisms responsible for these changes, this study controlled for the potentially confounding effects of dopaminergic medication, depression, anxiety, and global cognitive impairment. The findings of the current study add to the literature by highlighting potential abnormalities in mesocorticolimbic pathways involved in the development of apathy in PD. Frontiers Media S.A. 2020-08-04 /pmc/articles/PMC7417661/ /pubmed/32848582 http://dx.doi.org/10.3389/fnins.2020.00830 Text en Copyright © 2020 Sun, Hu, Chen, Wang, Wang, Pan and Liu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Sun, Hai-Hua
Hu, Jian-Bin
Chen, Jing
Wang, Xue-Yang
Wang, Xiao-Li
Pan, Ping-Lei
Liu, Chun-Feng
Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy
title Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy
title_full Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy
title_fullStr Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy
title_full_unstemmed Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy
title_short Abnormal Spontaneous Neural Activity in Parkinson’s Disease With “pure” Apathy
title_sort abnormal spontaneous neural activity in parkinson’s disease with “pure” apathy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417661/
https://www.ncbi.nlm.nih.gov/pubmed/32848582
http://dx.doi.org/10.3389/fnins.2020.00830
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