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Osteopontin as a candidate of therapeutic application for the acute brain injury
Acute brain injury is the leading cause of human death and disability worldwide, which includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia, traumatic brain injury and hypoxia‐ischaemia brain injury. Currently, clinical treatments for neurological dysfunction of acute bra...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417697/ https://www.ncbi.nlm.nih.gov/pubmed/32657030 http://dx.doi.org/10.1111/jcmm.15641 |
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author | Zhou, Yunxiang Yao, Yihan Sheng, Lesang Zhang, Jianmin Zhang, John H. Shao, Anwen |
author_facet | Zhou, Yunxiang Yao, Yihan Sheng, Lesang Zhang, Jianmin Zhang, John H. Shao, Anwen |
author_sort | Zhou, Yunxiang |
collection | PubMed |
description | Acute brain injury is the leading cause of human death and disability worldwide, which includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia, traumatic brain injury and hypoxia‐ischaemia brain injury. Currently, clinical treatments for neurological dysfunction of acute brain injury have not been satisfactory. Osteopontin (OPN) is a complex adhesion protein and cytokine that interacts with multiple receptors including integrins and CD44 variants, exhibiting mostly neuroprotective roles and showing therapeutic potential for acute brain injury. OPN‐induced tissue remodelling and functional repair mainly rely on its positive roles in the coordination of pro‐inflammatory and anti‐inflammatory responses, blood‐brain barrier maintenance and anti‐apoptotic actions, as well as other mechanisms such as affecting the chemotaxis and proliferation of nerve cells. The blood OPN strongly parallel with the OPN induced in the brain and can be used as a novel biomarker of the susceptibility, severity and outcome of acute brain injury. In the present review, we summarized the molecular signalling mechanisms of OPN as well as its overall role in different kinds of acute brain injury. |
format | Online Article Text |
id | pubmed-7417697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74176972020-08-11 Osteopontin as a candidate of therapeutic application for the acute brain injury Zhou, Yunxiang Yao, Yihan Sheng, Lesang Zhang, Jianmin Zhang, John H. Shao, Anwen J Cell Mol Med Reviews Acute brain injury is the leading cause of human death and disability worldwide, which includes intracerebral haemorrhage, subarachnoid haemorrhage, cerebral ischaemia, traumatic brain injury and hypoxia‐ischaemia brain injury. Currently, clinical treatments for neurological dysfunction of acute brain injury have not been satisfactory. Osteopontin (OPN) is a complex adhesion protein and cytokine that interacts with multiple receptors including integrins and CD44 variants, exhibiting mostly neuroprotective roles and showing therapeutic potential for acute brain injury. OPN‐induced tissue remodelling and functional repair mainly rely on its positive roles in the coordination of pro‐inflammatory and anti‐inflammatory responses, blood‐brain barrier maintenance and anti‐apoptotic actions, as well as other mechanisms such as affecting the chemotaxis and proliferation of nerve cells. The blood OPN strongly parallel with the OPN induced in the brain and can be used as a novel biomarker of the susceptibility, severity and outcome of acute brain injury. In the present review, we summarized the molecular signalling mechanisms of OPN as well as its overall role in different kinds of acute brain injury. John Wiley and Sons Inc. 2020-07-13 2020-08 /pmc/articles/PMC7417697/ /pubmed/32657030 http://dx.doi.org/10.1111/jcmm.15641 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Zhou, Yunxiang Yao, Yihan Sheng, Lesang Zhang, Jianmin Zhang, John H. Shao, Anwen Osteopontin as a candidate of therapeutic application for the acute brain injury |
title | Osteopontin as a candidate of therapeutic application for the acute brain injury |
title_full | Osteopontin as a candidate of therapeutic application for the acute brain injury |
title_fullStr | Osteopontin as a candidate of therapeutic application for the acute brain injury |
title_full_unstemmed | Osteopontin as a candidate of therapeutic application for the acute brain injury |
title_short | Osteopontin as a candidate of therapeutic application for the acute brain injury |
title_sort | osteopontin as a candidate of therapeutic application for the acute brain injury |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417697/ https://www.ncbi.nlm.nih.gov/pubmed/32657030 http://dx.doi.org/10.1111/jcmm.15641 |
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