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PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety...

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Detalles Bibliográficos
Autores principales:	Helou, Doumet Georges, Shafiei-Jahani, Pedram, Lo, Richard, Howard, Emily, Hurrell, Benjamin P., Galle-Treger, Lauriane, Painter, Jacob D., Lewis, Gavin, Soroosh, Pejman, Sharpe, Arlene H., Akbari, Omid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417739/ https://www.ncbi.nlm.nih.gov/pubmed/32778730 http://dx.doi.org/10.1038/s41467-020-17813-1

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