Antagonistic effects of IL-17 and Astragaloside IV on cortical neurogenesis and cognitive behavior after stroke in adult mice through Akt/GSK-3β pathway

We aimed to investigate the exact effect of IL-17 on regulating neural stem cells (NSCs) stemness and adult neurogenesis in ischemic cortex after stroke, how Astragaloside IV(As-IV) regulated IL-17 expression and the underlying mechanism. Photochemical brain ischemia model was established and IL-17...

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Detalles Bibliográficos
Autores principales: Sun, Li, Han, Ruili, Guo, Fei, Chen, Hai, Wang, Wen, Chen, Zhiyang, Liu, Wei, Sun, Xude, Gao, Changjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417740/
https://www.ncbi.nlm.nih.gov/pubmed/32818074
http://dx.doi.org/10.1038/s41420-020-00298-8

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