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Biosensors: frontiers in rapid detection of COVID-19
The rapid community-spread of novel human coronavirus 2019 (nCOVID19 or SARS-Cov2) and morbidity statistics has put forth an unprecedented urge for rapid diagnostics for quick and sensitive detection followed by contact tracing and containment strategies, especially when no vaccine or therapeutics a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417775/ https://www.ncbi.nlm.nih.gov/pubmed/32818132 http://dx.doi.org/10.1007/s13205-020-02369-0 |
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author | Samson, Rachel Navale, Govinda R. Dharne, Mahesh S. |
author_facet | Samson, Rachel Navale, Govinda R. Dharne, Mahesh S. |
author_sort | Samson, Rachel |
collection | PubMed |
description | The rapid community-spread of novel human coronavirus 2019 (nCOVID19 or SARS-Cov2) and morbidity statistics has put forth an unprecedented urge for rapid diagnostics for quick and sensitive detection followed by contact tracing and containment strategies, especially when no vaccine or therapeutics are known. Currently, quantitative real-time polymerase chain reaction (qRT-PCR) is being used widely to detect COVID-19 from various types of biological specimens, which is time-consuming, labor-intensive and may not be rapidly deployable in remote or resource-limited settings. This might lead to hindrance in acquiring realistic data of infectivity and community spread of SARS-CoV-2 in the population. This review summarizes the existing status of current diagnostic methods, their possible limitations, and the advantages of biosensor-based diagnostics over the conventional ones for the detection of SARS-Cov-2. Novel biosensors used to detect RNA-viruses include CRISPR-Cas9 based paper strip, nucleic-acid based, aptamer-based, antigen-Au/Ag nanoparticles-based electrochemical biosensor, optical biosensor, and Surface Plasmon Resonance. These could be effective tools for rapid, authentic, portable, and more promising diagnosis in the current pandemic that has affected the world economies and humanity. Present challenges and future perspectives of developing robust biosensors devices for rapid, scalable, and sensitive detection and management of COVID-19 are presented in light of the test-test-test theme of the World Health Organization (WHO). |
format | Online Article Text |
id | pubmed-7417775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-74177752020-08-11 Biosensors: frontiers in rapid detection of COVID-19 Samson, Rachel Navale, Govinda R. Dharne, Mahesh S. 3 Biotech Review Article The rapid community-spread of novel human coronavirus 2019 (nCOVID19 or SARS-Cov2) and morbidity statistics has put forth an unprecedented urge for rapid diagnostics for quick and sensitive detection followed by contact tracing and containment strategies, especially when no vaccine or therapeutics are known. Currently, quantitative real-time polymerase chain reaction (qRT-PCR) is being used widely to detect COVID-19 from various types of biological specimens, which is time-consuming, labor-intensive and may not be rapidly deployable in remote or resource-limited settings. This might lead to hindrance in acquiring realistic data of infectivity and community spread of SARS-CoV-2 in the population. This review summarizes the existing status of current diagnostic methods, their possible limitations, and the advantages of biosensor-based diagnostics over the conventional ones for the detection of SARS-Cov-2. Novel biosensors used to detect RNA-viruses include CRISPR-Cas9 based paper strip, nucleic-acid based, aptamer-based, antigen-Au/Ag nanoparticles-based electrochemical biosensor, optical biosensor, and Surface Plasmon Resonance. These could be effective tools for rapid, authentic, portable, and more promising diagnosis in the current pandemic that has affected the world economies and humanity. Present challenges and future perspectives of developing robust biosensors devices for rapid, scalable, and sensitive detection and management of COVID-19 are presented in light of the test-test-test theme of the World Health Organization (WHO). Springer International Publishing 2020-08-11 2020-09 /pmc/articles/PMC7417775/ /pubmed/32818132 http://dx.doi.org/10.1007/s13205-020-02369-0 Text en © King Abdulaziz City for Science and Technology 2020 |
spellingShingle | Review Article Samson, Rachel Navale, Govinda R. Dharne, Mahesh S. Biosensors: frontiers in rapid detection of COVID-19 |
title | Biosensors: frontiers in rapid detection of COVID-19 |
title_full | Biosensors: frontiers in rapid detection of COVID-19 |
title_fullStr | Biosensors: frontiers in rapid detection of COVID-19 |
title_full_unstemmed | Biosensors: frontiers in rapid detection of COVID-19 |
title_short | Biosensors: frontiers in rapid detection of COVID-19 |
title_sort | biosensors: frontiers in rapid detection of covid-19 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417775/ https://www.ncbi.nlm.nih.gov/pubmed/32818132 http://dx.doi.org/10.1007/s13205-020-02369-0 |
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