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Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress

Magnetic γ-Fe(2)O(3)/CeO(x) nanoparticles were obtained by basic coprecipitation/oxidation of iron chlorides with hydrogen peroxide, followed by precipitation of Ce(NO(3))(3) with ammonia. The appearance of CeO(x) on the magnetic particle surface was confirmed by X-ray photoelectron spectroscopy (XP...

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Autores principales: Moskvin, Maksym, Marková, Irena, Malínská, Hana, Miklánková, Denisa, Hüttl, Martina, Oliyarnyk, Olena, Pop-Georgievski, Ognen, Zhigunov, Alexander, Petrovský, Eduard, Horák, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417791/
https://www.ncbi.nlm.nih.gov/pubmed/32850680
http://dx.doi.org/10.3389/fchem.2020.00682
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author Moskvin, Maksym
Marková, Irena
Malínská, Hana
Miklánková, Denisa
Hüttl, Martina
Oliyarnyk, Olena
Pop-Georgievski, Ognen
Zhigunov, Alexander
Petrovský, Eduard
Horák, Daniel
author_facet Moskvin, Maksym
Marková, Irena
Malínská, Hana
Miklánková, Denisa
Hüttl, Martina
Oliyarnyk, Olena
Pop-Georgievski, Ognen
Zhigunov, Alexander
Petrovský, Eduard
Horák, Daniel
author_sort Moskvin, Maksym
collection PubMed
description Magnetic γ-Fe(2)O(3)/CeO(x) nanoparticles were obtained by basic coprecipitation/oxidation of iron chlorides with hydrogen peroxide, followed by precipitation of Ce(NO(3))(3) with ammonia. The appearance of CeO(x) on the magnetic particle surface was confirmed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), and elemental analysis; a magnetometer was used to measure the magnetic properties of γ-Fe(2)O(3)/CeO(x). The relatively high saturation magnetization of the particles (41.1 A·m(2)/kg) enabled magnetic separation. The surface of γ-Fe(2)O(3)/CeO(x) particles was functionalized with PEG-neridronate of two different molecular weights to ensure colloidal stability and biocompatibility. The ability of the particles to affect oxidative stress in hereditary hypertriglyceridemic (HHTg) rats was tested by biological assay of the liver, kidney cortex, and brain tissues. An improvement was observed in both enzymatic [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)] and non-enzymatic (reduced (GSH) and oxidized (GSSG) glutathione) levels of antioxidant defense and lipid peroxidation parameters [4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)]. The results corresponded with chemical determination of antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, proving that in the animal model γ-Fe(2)O(3)/CeO(x)@PEG(2,000) nanoparticles effectively scavenged radicals due to the presence of cerium oxide, in turn decreasing oxidative stress. These particles may therefore have the potential to reduce disorders associated with oxidative stress and inflammation.
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spelling pubmed-74177912020-08-25 Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress Moskvin, Maksym Marková, Irena Malínská, Hana Miklánková, Denisa Hüttl, Martina Oliyarnyk, Olena Pop-Georgievski, Ognen Zhigunov, Alexander Petrovský, Eduard Horák, Daniel Front Chem Chemistry Magnetic γ-Fe(2)O(3)/CeO(x) nanoparticles were obtained by basic coprecipitation/oxidation of iron chlorides with hydrogen peroxide, followed by precipitation of Ce(NO(3))(3) with ammonia. The appearance of CeO(x) on the magnetic particle surface was confirmed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), and elemental analysis; a magnetometer was used to measure the magnetic properties of γ-Fe(2)O(3)/CeO(x). The relatively high saturation magnetization of the particles (41.1 A·m(2)/kg) enabled magnetic separation. The surface of γ-Fe(2)O(3)/CeO(x) particles was functionalized with PEG-neridronate of two different molecular weights to ensure colloidal stability and biocompatibility. The ability of the particles to affect oxidative stress in hereditary hypertriglyceridemic (HHTg) rats was tested by biological assay of the liver, kidney cortex, and brain tissues. An improvement was observed in both enzymatic [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)] and non-enzymatic (reduced (GSH) and oxidized (GSSG) glutathione) levels of antioxidant defense and lipid peroxidation parameters [4-hydroxynonenal (4-HNE) and malondialdehyde (MDA)]. The results corresponded with chemical determination of antioxidant activity based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, proving that in the animal model γ-Fe(2)O(3)/CeO(x)@PEG(2,000) nanoparticles effectively scavenged radicals due to the presence of cerium oxide, in turn decreasing oxidative stress. These particles may therefore have the potential to reduce disorders associated with oxidative stress and inflammation. Frontiers Media S.A. 2020-08-04 /pmc/articles/PMC7417791/ /pubmed/32850680 http://dx.doi.org/10.3389/fchem.2020.00682 Text en Copyright © 2020 Moskvin, Marková, Malínská, Miklánková, Hüttl, Oliyarnyk, Pop-Georgievski, Zhigunov, Petrovský and Horák. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Moskvin, Maksym
Marková, Irena
Malínská, Hana
Miklánková, Denisa
Hüttl, Martina
Oliyarnyk, Olena
Pop-Georgievski, Ognen
Zhigunov, Alexander
Petrovský, Eduard
Horák, Daniel
Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress
title Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress
title_full Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress
title_fullStr Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress
title_full_unstemmed Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress
title_short Cerium Oxide-Decorated γ-Fe(2)O(3) Nanoparticles: Design, Synthesis and in vivo Effects on Parameters of Oxidative Stress
title_sort cerium oxide-decorated γ-fe(2)o(3) nanoparticles: design, synthesis and in vivo effects on parameters of oxidative stress
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417791/
https://www.ncbi.nlm.nih.gov/pubmed/32850680
http://dx.doi.org/10.3389/fchem.2020.00682
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