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Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

INTRODUCTION: The NLRP3 inflammasome produces interleukin (IL)-1β and IL-18, which when chronically activated by transforming growth factor (TGF)-β1, contribute to fibrosis. The recombinant form of the anti-fibrotic hormone, relaxin (RLX), suppresses the pro-fibrotic influence of TGF-β1 and toll-lik...

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Detalles Bibliográficos
Autores principales:	Pinar, Anita A., Yuferov, Alexander, Gaspari, Tracey A., Samuel, Chrishan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417934/ https://www.ncbi.nlm.nih.gov/pubmed/32848798 http://dx.doi.org/10.3389/fphar.2020.01201

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