Use of Multimodal Imaging and Clinical Biomarkers in Presymptomatic Carriers of C9orf72 Repeat Expansion

IMPORTANCE: During a time with the potential for novel treatment strategies, early detection of disease manifestations at an individual level in presymptomatic carriers of a hexanucleotide repeat expansion in the C9orf72 gene (preSxC9) is becoming increasingly relevant. OBJECTIVES: To evaluate chang...

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Detalles Bibliográficos
Autores principales: De Vocht, Joke, Blommaert, Jeroen, Devrome, Martijn, Radwan, Ahmed, Van Weehaeghe, Donatienne, De Schaepdryver, Maxim, Ceccarini, Jenny, Rezaei, Ahmadreza, Schramm, Georg, van Aalst, June, Chiò, Adriano, Pagani, Marco, Stam, Daphne, Van Esch, Hilde, Lamaire, Nikita, Verhaegen, Marianne, Mertens, Nathalie, Poesen, Koen, van den Berg, Leonard H., van Es, Michael A., Vandenberghe, Rik, Vandenbulcke, Mathieu, Van den Stock, Jan, Koole, Michel, Dupont, Patrick, Van Laere, Koen, Van Damme, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2020
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417970/
https://www.ncbi.nlm.nih.gov/pubmed/32421156
http://dx.doi.org/10.1001/jamaneurol.2020.1087

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