Copper-Catalyzed Modular Assembly of Polyheterocycles

[Image: see text] Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia–Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence....

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Detalles Bibliográficos
Autores principales: Wang, Qian, Tuinhof, Jesse, Mgimpatsang, Kumchok C., Kurpiewska, Katarzyna, Kalinowska-Tluscik, Justyna, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418108/
https://www.ncbi.nlm.nih.gov/pubmed/32615764
http://dx.doi.org/10.1021/acs.joc.0c01238
Descripción
Sumario:[Image: see text] Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia–Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.

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