Copper-Catalyzed Modular Assembly of Polyheterocycles

[Image: see text] Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia–Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence....

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Autores principales: Wang, Qian, Tuinhof, Jesse, Mgimpatsang, Kumchok C., Kurpiewska, Katarzyna, Kalinowska-Tluscik, Justyna, Dömling, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418108/
https://www.ncbi.nlm.nih.gov/pubmed/32615764
http://dx.doi.org/10.1021/acs.joc.0c01238
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author Wang, Qian
Tuinhof, Jesse
Mgimpatsang, Kumchok C.
Kurpiewska, Katarzyna
Kalinowska-Tluscik, Justyna
Dömling, Alexander
author_facet Wang, Qian
Tuinhof, Jesse
Mgimpatsang, Kumchok C.
Kurpiewska, Katarzyna
Kalinowska-Tluscik, Justyna
Dömling, Alexander
author_sort Wang, Qian
collection PubMed
description [Image: see text] Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia–Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.
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spelling pubmed-74181082020-08-11 Copper-Catalyzed Modular Assembly of Polyheterocycles Wang, Qian Tuinhof, Jesse Mgimpatsang, Kumchok C. Kurpiewska, Katarzyna Kalinowska-Tluscik, Justyna Dömling, Alexander J Org Chem [Image: see text] Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-c]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia–Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps. American Chemical Society 2020-07-03 2020-08-07 /pmc/articles/PMC7418108/ /pubmed/32615764 http://dx.doi.org/10.1021/acs.joc.0c01238 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Wang, Qian
Tuinhof, Jesse
Mgimpatsang, Kumchok C.
Kurpiewska, Katarzyna
Kalinowska-Tluscik, Justyna
Dömling, Alexander
Copper-Catalyzed Modular Assembly of Polyheterocycles
title Copper-Catalyzed Modular Assembly of Polyheterocycles
title_full Copper-Catalyzed Modular Assembly of Polyheterocycles
title_fullStr Copper-Catalyzed Modular Assembly of Polyheterocycles
title_full_unstemmed Copper-Catalyzed Modular Assembly of Polyheterocycles
title_short Copper-Catalyzed Modular Assembly of Polyheterocycles
title_sort copper-catalyzed modular assembly of polyheterocycles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418108/
https://www.ncbi.nlm.nih.gov/pubmed/32615764
http://dx.doi.org/10.1021/acs.joc.0c01238
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