Therapeutic inhibition of microRNA-21 (miR-21) using locked-nucleic acid (LNA)-anti-miR and its effects on the biological behaviors of melanoma cancer cells in preclinical studies

BACKGROUND: Melanoma is a cancer that has a high mortality rate in the absence of targeted therapy. Conventional therapies such as surgery, chemotherapy, and radiotherapy are associated with poor prognosis. The expression of miR-21 appears to be of clinical importance, and the regulation of its expr...

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Detalles Bibliográficos
Autores principales: Javanmard, Shaghayegh Haghjooy, Vaseghi, Golnaz, Ghasemi, Ahmad, Rafiee, Laleh, Ferns, Gordon A., Esfahani, Hajar Naji, Nedaeinia, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418194/
https://www.ncbi.nlm.nih.gov/pubmed/32788885
http://dx.doi.org/10.1186/s12935-020-01394-6

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