Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions

[Image: see text] Peroxyzymes simply use H(2)O(2) as a cosubstrate to oxidize a broad range of inert C–H bonds. The lability of many peroxyzymes against H(2)O(2) can be addressed by a controlled supply of H(2)O(2), ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone su...

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Autores principales: Yuan, Bo, Mahor, Durga, Fei, Qiang, Wever, Ron, Alcalde, Miguel, Zhang, Wuyuan, Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418218/
https://www.ncbi.nlm.nih.gov/pubmed/32802571
http://dx.doi.org/10.1021/acscatal.0c01958
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author Yuan, Bo
Mahor, Durga
Fei, Qiang
Wever, Ron
Alcalde, Miguel
Zhang, Wuyuan
Hollmann, Frank
author_facet Yuan, Bo
Mahor, Durga
Fei, Qiang
Wever, Ron
Alcalde, Miguel
Zhang, Wuyuan
Hollmann, Frank
author_sort Yuan, Bo
collection PubMed
description [Image: see text] Peroxyzymes simply use H(2)O(2) as a cosubstrate to oxidize a broad range of inert C–H bonds. The lability of many peroxyzymes against H(2)O(2) can be addressed by a controlled supply of H(2)O(2), ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H(2)O(2) generation. Very promising turnover numbers for the biocatalysts of up to 318 000 have been achieved.
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spelling pubmed-74182182020-08-12 Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions Yuan, Bo Mahor, Durga Fei, Qiang Wever, Ron Alcalde, Miguel Zhang, Wuyuan Hollmann, Frank ACS Catal [Image: see text] Peroxyzymes simply use H(2)O(2) as a cosubstrate to oxidize a broad range of inert C–H bonds. The lability of many peroxyzymes against H(2)O(2) can be addressed by a controlled supply of H(2)O(2), ideally in situ. Here, we report a simple, robust, and water-soluble anthraquinone sulfonate (SAS) as a promising organophotocatalyst to drive both haloperoxidase-catalyzed halogenation and peroxygenase-catalyzed oxyfunctionalization reactions. Simple alcohols, methanol in particular, can be used both as a cosolvent and an electron donor for H(2)O(2) generation. Very promising turnover numbers for the biocatalysts of up to 318 000 have been achieved. American Chemical Society 2020-06-30 2020-08-07 /pmc/articles/PMC7418218/ /pubmed/32802571 http://dx.doi.org/10.1021/acscatal.0c01958 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Yuan, Bo
Mahor, Durga
Fei, Qiang
Wever, Ron
Alcalde, Miguel
Zhang, Wuyuan
Hollmann, Frank
Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions
title Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions
title_full Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions
title_fullStr Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions
title_full_unstemmed Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions
title_short Water-Soluble Anthraquinone Photocatalysts Enable Methanol-Driven Enzymatic Halogenation and Hydroxylation Reactions
title_sort water-soluble anthraquinone photocatalysts enable methanol-driven enzymatic halogenation and hydroxylation reactions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418218/
https://www.ncbi.nlm.nih.gov/pubmed/32802571
http://dx.doi.org/10.1021/acscatal.0c01958
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