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Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States

BACKGROUND: Azoospermia is present in 10% of men presenting with infertility and surgical sperm retrieval rates for men with azoospermia due to spermatogenic dysfunction remain low. We investigated the incidence of failed fresh IVF cycles due to inability to obtain sperm and describe predictors for...

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Autores principales: Berger, Alexandra Joice, Raup, Valary, Abou Ghayda, Ramy, Lanes, Andrea, Kathrins, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418387/
https://www.ncbi.nlm.nih.gov/pubmed/32793376
http://dx.doi.org/10.1186/s40738-020-00082-3
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author Berger, Alexandra Joice
Raup, Valary
Abou Ghayda, Ramy
Lanes, Andrea
Kathrins, Martin
author_facet Berger, Alexandra Joice
Raup, Valary
Abou Ghayda, Ramy
Lanes, Andrea
Kathrins, Martin
author_sort Berger, Alexandra Joice
collection PubMed
description BACKGROUND: Azoospermia is present in 10% of men presenting with infertility and surgical sperm retrieval rates for men with azoospermia due to spermatogenic dysfunction remain low. We investigated the incidence of failed fresh IVF cycles due to inability to obtain sperm and describe predictors for subsequent IVF. METHODS: A national IVF database was used to identify fresh IVF cycles in which there was failure to obtain sperm. Patient linkage was utilized to determine outcomes of subsequent IVF. RESULTS: 243,291 fresh IVF cycles were identified; 719 (0.3%) listed “inability to obtain sperm” as reason for embryo non-transfer. Male infertility was a factor in 537 (75%) and ejaculation was the most common anticipated sperm source (414, 57%). 713 (99.2%) cycles resulted in retrieved oocytes, but only 627 (87.2%) cryopreserved oocytes. 265 (37%) of couples underwent subsequent IVF. On multivariable analysis, lack of initial oocyte cryopreservation (OR 0.34, p = 0.01) and male infertility (OR 0.14, p = 0.01) were associated with having no subsequent cycles. Partner sperm was used in 213 (80%) second cycles and sperm retrieval method was largely conserved (181/213, 85%). Embryos were transferred in 186 (70%) second cycles. Failed embryo transfers were due to repeat inability to obtain sperm in 5 (6%) cycles. CONCLUSIONS: Failure to obtain sperm during fresh IVF is rare, but most affected couples will not pursue further cycles of IVF after their initial failed attempt.
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spelling pubmed-74183872020-08-12 Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States Berger, Alexandra Joice Raup, Valary Abou Ghayda, Ramy Lanes, Andrea Kathrins, Martin Fertil Res Pract Research Article BACKGROUND: Azoospermia is present in 10% of men presenting with infertility and surgical sperm retrieval rates for men with azoospermia due to spermatogenic dysfunction remain low. We investigated the incidence of failed fresh IVF cycles due to inability to obtain sperm and describe predictors for subsequent IVF. METHODS: A national IVF database was used to identify fresh IVF cycles in which there was failure to obtain sperm. Patient linkage was utilized to determine outcomes of subsequent IVF. RESULTS: 243,291 fresh IVF cycles were identified; 719 (0.3%) listed “inability to obtain sperm” as reason for embryo non-transfer. Male infertility was a factor in 537 (75%) and ejaculation was the most common anticipated sperm source (414, 57%). 713 (99.2%) cycles resulted in retrieved oocytes, but only 627 (87.2%) cryopreserved oocytes. 265 (37%) of couples underwent subsequent IVF. On multivariable analysis, lack of initial oocyte cryopreservation (OR 0.34, p = 0.01) and male infertility (OR 0.14, p = 0.01) were associated with having no subsequent cycles. Partner sperm was used in 213 (80%) second cycles and sperm retrieval method was largely conserved (181/213, 85%). Embryos were transferred in 186 (70%) second cycles. Failed embryo transfers were due to repeat inability to obtain sperm in 5 (6%) cycles. CONCLUSIONS: Failure to obtain sperm during fresh IVF is rare, but most affected couples will not pursue further cycles of IVF after their initial failed attempt. BioMed Central 2020-08-11 /pmc/articles/PMC7418387/ /pubmed/32793376 http://dx.doi.org/10.1186/s40738-020-00082-3 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Berger, Alexandra Joice
Raup, Valary
Abou Ghayda, Ramy
Lanes, Andrea
Kathrins, Martin
Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States
title Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States
title_full Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States
title_fullStr Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States
title_full_unstemmed Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States
title_short Inability to obtain sperm for fresh IVF cycles: analysis and incidence of outcomes using a database from the United States
title_sort inability to obtain sperm for fresh ivf cycles: analysis and incidence of outcomes using a database from the united states
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418387/
https://www.ncbi.nlm.nih.gov/pubmed/32793376
http://dx.doi.org/10.1186/s40738-020-00082-3
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