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Impact of HIV-1 Vpr manipulation of the DNA repair enzyme UNG2 on B lymphocyte class switch recombination

BACKGROUND: HIV-1 Vpr encodes a 14 kDa protein that has been implicated in viral pathogenesis through modulation of several host cell functions. In addition to pro-apoptotic and cytostatic properties, Vpr can redirect cellular E3 ubiquitin ligases (such as DCAF1-Cul4A E3 ligase complex) to target ma...

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Detalles Bibliográficos
Autores principales:	Eldin, Patrick, Péron, Sophie, Galashevskaya, Anastasia, Denis-Lagache, Nicolas, Cogné, Michel, Slupphaug, Geir, Briant, Laurence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418440/ https://www.ncbi.nlm.nih.gov/pubmed/32778120 http://dx.doi.org/10.1186/s12967-020-02478-7

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