Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells

BACKGROUND: Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be avoided by lowered permissible exposure levels. In this stud...

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Detalles Bibliográficos
Autores principales: Wu, Rongrong, Högberg, Johan, Adner, Mikael, Ramos-Ramírez, Patricia, Stenius, Ulla, Zheng, Huiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418441/
https://www.ncbi.nlm.nih.gov/pubmed/32778128
http://dx.doi.org/10.1186/s12989-020-00370-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418441/
https://www.ncbi.nlm.nih.gov/pubmed/32778128
http://dx.doi.org/10.1186/s12989-020-00370-2

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