Cargando…

Crystalline silica particles cause rapid NLRP3-dependent mitochondrial depolarization and DNA damage in airway epithelial cells

BACKGROUND: Respirable crystalline silica causes lung carcinomas and many thousand future cancer cases are expected in e.g. Europe. Critical questions are how silica causes genotoxicity in the respiratory epithelium and if new cases can be avoided by lowered permissible exposure levels. In this stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Rongrong, Högberg, Johan, Adner, Mikael, Ramos-Ramírez, Patricia, Stenius, Ulla, Zheng, Huiyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418441/ https://www.ncbi.nlm.nih.gov/pubmed/32778128 http://dx.doi.org/10.1186/s12989-020-00370-2

Ejemplares similares

ATX-LPA-Dependent Nuclear Translocation of Endonuclease G in Respiratory Epithelial Cells: A New Mode Action for DNA Damage Induced by Crystalline Silica Particles
por: Zheng, Huiyuan, et al.
Publicado: (2023)

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) and PH Domain and Leucine-rich Repeat Phosphatase Cross-talk (PHLPP) in Cancer Cells and in Transforming Growth Factor β-Activated Stem Cells
por: Ghalali, Aram, et al.
Publicado: (2014)

A comparison and user-based evaluation of models of textual information structure in the context of cancer risk assessment
por: Guo, Yufan, et al.
Publicado: (2011)

Application of Text Mining in Risk Assessment of Chemical Mixtures: A Case Study of Polycyclic Aromatic Hydrocarbons (PAHs)
por: Ali, Imran, et al.
Publicado: (2021)

Lung Regulatory T Cells Express Adiponectin Receptor 1: Modulation by Obesity and Airway Allergic Inflammation
por: Ramos-Ramírez, Patricia, et al.
Publicado: (2020)

Text Mining for Literature Review and Knowledge Discovery in Cancer Risk Assessment and Research
por: Korhonen, Anna, et al.
Publicado: (2012)

Exocrine Pancreatic Carcinogenesis and Autotaxin Expression
por: Kadekar, Sandeep, et al.
Publicado: (2012)

Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model
por: Skuland, Tonje, et al.
Publicado: (2020)

Cancer Hallmarks Analytics Tool (CHAT): a text mining approach to organize and evaluate scientific literature on cancer
por: Baker, Simon, et al.
Publicado: (2017)

Crystalline silica: risks and policy.
por: Hardy, T S, et al.
Publicado: (1995)

Silica induces NLRP3 inflammasome activation in human lung epithelial cells
por: Peeters, Paul M, et al.
Publicado: (2013)

IL-1β induces murine airway 5-HT(2A )receptor hyperresponsiveness via a non-transcriptional MAPK-dependent mechanism
por: Zhang, Yaping, et al.
Publicado: (2007)

Risk Analysis Implications of Dose-Response Thresholds for NLRP3 Inflammasome-Mediated Diseases: Respirable Crystalline Silica and Lung Cancer as an Example
por: Cox, Louis Anthony (Tony)
Publicado: (2019)

Occupational exposure to crystalline silica and autoimmune disease.
por: Parks, C G, et al.
Publicado: (1999)

An updated review of the genotoxicity of respirable crystalline silica
por: Borm, Paul J. A., et al.
Publicado: (2018)

The Flying Monkeys of Ozone: Oxysterols Inactivate NLRP2 in Airway Epithelial Cells
por: Hernandez, Pedro, et al.
Publicado: (2021)

Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells
por: Perkins, Timothy N, et al.
Publicado: (2012)

Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
por: Sanchez, Alicia, et al.
Publicado: (2017)

LION LBD: a literature-based discovery system for cancer biology
por: Pyysalo, Sampo, et al.
Publicado: (2019)

Toll-Like Receptor Ligands LPS and Poly (I:C) Exacerbate Airway Hyperresponsiveness in a Model of Airway Allergy in Mice, Independently of Inflammation
por: Starkhammar, Magnus, et al.
Publicado: (2014)

Vaccination against IL-33 Inhibits Airway Hyperresponsiveness and Inflammation in a House Dust Mite Model of Asthma
por: Lei, Ying, et al.
Publicado: (2015)

Mechanisms of carcinogenesis by crystalline silica in relation to oxygen radicals.
por: Saffiotti, U, et al.
Publicado: (1994)

Assessment of Occupational Exposure to Dust and Crystalline Silica in Foundries
por: Omidianidost, Ali, et al.
Publicado: (2015)

Liquid Crystalline Network Composites Reinforced by Silica Nanoparticles
por: Li, Zhen, et al.
Publicado: (2014)

Surface and bulk infrared modes of crystalline and amorphous silica particles: a study of the relation of surface structure to cytotoxicity of respirable silica.
por: Pandurangi, R S, et al.
Publicado: (1990)

Innate Immune Receptors in Human Airway Smooth Muscle Cells: Activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 Agonists
por: Månsson Kvarnhammar, Anne, et al.
Publicado: (2013)

Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models
por: Liu, Jielu, et al.
Publicado: (2022)

TNFα-blockade stabilizes local airway hyperresponsiveness during TLR-induced exacerbations in murine model of asthma
por: Starkhammar, Magnus, et al.
Publicado: (2015)

Silica Nanoparticles Inhibit Responses to ATP in Human Airway Epithelial 16HBE Cells
por: Milici, Alina, et al.
Publicado: (2021)

Questioning Glutamate Excitotoxicity in Acute Brain Damage: The Importance of Spreading Depolarization
por: Andrew, R. David, et al.
Publicado: (2022)

Evaluation of Respirable Crystalline Silica in High School Ceramics Classrooms
por: Fechser, Matthew, et al.
Publicado: (2014)

Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica
por: Zelko, Igor N., et al.
Publicado: (2016)

Depolarization of electrons
por: Robinson, K W
Publicado: (1967)

Crystalline Silica Impairs Efferocytosis Abilities of Human and Mouse Macrophages: Implication for Silica-Associated Systemic Sclerosis
por: Lescoat, Alain, et al.
Publicado: (2020)

Intranasal Administration of poly(I:C) and LPS in BALB/c Mice Induces Airway Hyperresponsiveness and Inflammation via Different Pathways
por: Starkhammar, Magnus, et al.
Publicado: (2012)

Occupational Exposure to Crystalline Silica Dust in the United States, 1988–2003
por: Yassin, Abdiaziz, et al.
Publicado: (2005)

DNA binding to crystalline silica characterized by Fourier-transform infrared spectroscopy.
por: Mao, Y, et al.
Publicado: (1994)

Assessing the bioactivity of crystalline silica in heated high-temperature insulation wools
por: Boyles, Matthew S. P., et al.
Publicado: (2018)

Occupational Exposures in an Equestrian Centre to Respirable Dust and Respirable Crystalline Silica
por: Bulfin, Kathleen, et al.
Publicado: (2019)

Mortality among mine and mill workers exposed to respirable crystalline silica
por: Kleinschmidt, Sarah E., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hbpo37fajt15dils3i34vubm72