Cargando…

Exploiting replicative stress in gynecological cancers as a therapeutic strategy

Elevated levels of replicative stress in gynecological cancers arising from uncontrolled oncogenic activation, loss of key tumor suppressors, and frequent defects in the DNA repair machinery are an intrinsic vulnerability for therapeutic exploitation. The presence of replication stress activates the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ngoi, Natalie YL, Sundararajan, Vignesh, Tan, David SP
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418601/ https://www.ncbi.nlm.nih.gov/pubmed/32571890 http://dx.doi.org/10.1136/ijgc-2020-001277

Ejemplares similares

The 4th European Society for Medical Oncology Asia Congress: bridging ultimate cancer care with real-world practice for the Asian practitioner in gynecological cancers
por: Ngoi, Natalie YL, et al.
Publicado: (2019)

Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer
por: Zhang, Jing, et al.
Publicado: (2022)

Update on immune checkpoint inhibitors in gynecological cancers
por: Heong, Valerie, et al.
Publicado: (2017)

Evolving Therapeutic Strategies to Exploit Chromosome Instability in Cancer
por: Thompson, Laura L., et al.
Publicado: (2017)

Everything in Moderation: Lessons Learned by Exploiting Moderate Replication Stress in Cancer
por: Nazareth, Deborah, et al.
Publicado: (2019)

Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer
por: Banno, Kouji, et al.
Publicado: (2015)

Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition
por: Sundararajan, Vignesh, et al.
Publicado: (2022)

A review of strategies to overcome immune resistance in the treatment of advanced prostate cancer
por: Sooi, Kenneth, et al.
Publicado: (2023)

The redox-senescence axis and its therapeutic targeting
por: Ngoi, Natalie YL., et al.
Publicado: (2021)

Therapeutic Targeting of DNA Replication Stress in Cancer
por: Gu, Long, et al.
Publicado: (2023)

Editorial: Molecular Targets and Therapeutic Strategies in Gynecological Cancers
por: Lu, Ziwen, et al.
Publicado: (2022)

A single-arm phase II study of olaparib maintenance with pembrolizumab and bevacizumab in BRCA non-mutated patients with platinum-sensitive recurrent ovarian cancer (OPEB-01)
por: Lee, Yong Jae, et al.
Publicado: (2021)

Apoptosis pathways and their therapeutic exploitation in pancreatic cancer
por: Fulda, Simone
Publicado: (2009)

Potential Antiviral Strategy Exploiting Dependence of SARS-CoV-2 Replication on Lysosome-Based Pathway
por: Lan, Yungang, et al.
Publicado: (2022)

Exploiting Connections for Viral Replication
por: Wong, Louise H., et al.
Publicado: (2021)

Activation of STAT3 and STAT5 Signaling in Epithelial Ovarian Cancer Progression: Mechanism and Therapeutic Opportunity
por: Wu, Chin-Jui, et al.
Publicado: (2019)

Exploiting LRRC15 as a Novel Therapeutic Target in Cancer
por: Ray, Upasana, et al.
Publicado: (2022)

Conservative Gynecology and Electro-Therapeutics
Publicado: (1899)

Pathophysiological Role and Potential Therapeutic Exploitation of Exosomes in Ovarian Cancer
por: Shimizu, Aasa, et al.
Publicado: (2020)

Therapeutic Approaches of Botulinum Toxin in Gynecology
por: Moga, Marius Alexandru, et al.
Publicado: (2018)

Macropinocytosis Exploitation by Cancers and Cancer Therapeutics
por: Ha, Kevin D., et al.
Publicado: (2016)

Therapeutic role of curcumin and its novel formulations in gynecological cancers
por: Pourhanifeh, Mohammad Hossein, et al.
Publicado: (2020)

Triplet maintenance therapy of olaparib, pembrolizumab and bevacizumab in women with BRCA wild-type, platinum-sensitive recurrent ovarian cancer: the multicenter, single-arm phase II study OPEB-01/APGOT-OV4
por: Kim, Yoo-Na, et al.
Publicado: (2023)

Novel Therapeutic Strategies Exploiting the Unique Properties of Neuroendocrine Neoplasms
por: Safari, Maryam, et al.
Publicado: (2023)

Neuroblastoma: oncogenic mechanisms and therapeutic exploitation of necroptosis
por: Nicolai, S, et al.
Publicado: (2015)

Strategies of exploitation of mammalian reservoirs by Bartonella species
por: Deng, Hongkuan, et al.
Publicado: (2012)

Angiogenesis: A Pivotal Therapeutic Target in the Drug Development of Gynecologic Cancers
por: Kasherman, Lawrence, et al.
Publicado: (2022)

Inhibition of DNA2 nuclease as a therapeutic strategy targeting replication stress in cancer cells
por: Kumar, S, et al.
Publicado: (2017)

Exploiting aneuploidy-imposed stresses and coping mechanisms to battle cancer
por: Zhou, Lin, et al.
Publicado: (2020)

Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma
por: Reyes-Uribe, Patricia, et al.
Publicado: (2018)

DDX11 loss causes replication stress and pharmacologically exploitable DNA repair defects
por: Jegadesan, Nanda Kumar, et al.
Publicado: (2021)

Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers
por: Mattox, Tyler E., et al.
Publicado: (2019)

Gynecologic Cancer Risk and Genetics: Informing an Ideal Model of Gynecologic Cancer Prevention
por: Tindale, Lauren C., et al.
Publicado: (2022)

Human Papillomavirus and the DNA Damage Response: Exploiting Host Repair Pathways for Viral Replication
por: Spriggs, Chelsey C., et al.
Publicado: (2017)

Exploiting Herpes Simplex Virus Entry for Novel Therapeutics
por: Hadigal, Satvik, et al.
Publicado: (2013)

Adaptation and Therapeutic Exploitation of the Plasma Membrane of African Trypanosomes
por: Quintana, Juan F., et al.
Publicado: (2018)

Exploiting the Complexities of Glioblastoma Stem Cells: Insights for Cancer Initiation and Therapeutic Targeting
por: Vieira de Castro, Joana, et al.
Publicado: (2020)

Implications of reactive oxygen species in lung cancer and exploiting it for therapeutic interventions
por: ArulJothi, K. N., et al.
Publicado: (2022)

Electro-Therapeutics of Gynecology
Publicado: (1893)

Role of Pyroptosis in Gynecological Oncology and Its Therapeutic Regulation
por: Huang, Yi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_86s07fnaag2kgglgv4bn1sgog4