The Duffy T-33C is an insightful marker of human history and admixture

A contrasting genotype and allele frequency pattern between Africans and non-Africans in the Duffy (T-33C) locus is reported. Its near fixation in various populations suggest is no longer under natural selection, and that current distribution is possibly a relic of distant extreme selection combined...

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Detalles Bibliográficos
Autores principales: Ali Albsheer, Musab M., Hussien, Ayman, Kwiatkowski, Dominic, Hamid, Muzamil Mahdi Abdel, Ibrahim, Muntaser E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418637/
https://www.ncbi.nlm.nih.gov/pubmed/32837914
http://dx.doi.org/10.1016/j.mgene.2020.100782
Descripción
Sumario:A contrasting genotype and allele frequency pattern between Africans and non-Africans in the Duffy (T-33C) locus is reported. Its near fixation in various populations suggest is no longer under natural selection, and that current distribution is possibly a relic of distant extreme selection combined with genetic drift during the out of Africa. We put this difference into the utility to infer the ancestral state of ambiguous loci in different populations.

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