The Duffy T-33C is an insightful marker of human history and admixture

A contrasting genotype and allele frequency pattern between Africans and non-Africans in the Duffy (T-33C) locus is reported. Its near fixation in various populations suggest is no longer under natural selection, and that current distribution is possibly a relic of distant extreme selection combined...

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Autores principales: Ali Albsheer, Musab M., Hussien, Ayman, Kwiatkowski, Dominic, Hamid, Muzamil Mahdi Abdel, Ibrahim, Muntaser E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418637/
https://www.ncbi.nlm.nih.gov/pubmed/32837914
http://dx.doi.org/10.1016/j.mgene.2020.100782
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author Ali Albsheer, Musab M.
Hussien, Ayman
Kwiatkowski, Dominic
Hamid, Muzamil Mahdi Abdel
Ibrahim, Muntaser E.
author_facet Ali Albsheer, Musab M.
Hussien, Ayman
Kwiatkowski, Dominic
Hamid, Muzamil Mahdi Abdel
Ibrahim, Muntaser E.
author_sort Ali Albsheer, Musab M.
collection PubMed
description A contrasting genotype and allele frequency pattern between Africans and non-Africans in the Duffy (T-33C) locus is reported. Its near fixation in various populations suggest is no longer under natural selection, and that current distribution is possibly a relic of distant extreme selection combined with genetic drift during the out of Africa. We put this difference into the utility to infer the ancestral state of ambiguous loci in different populations.
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spelling pubmed-74186372020-08-12 The Duffy T-33C is an insightful marker of human history and admixture Ali Albsheer, Musab M. Hussien, Ayman Kwiatkowski, Dominic Hamid, Muzamil Mahdi Abdel Ibrahim, Muntaser E. Meta Gene Article A contrasting genotype and allele frequency pattern between Africans and non-Africans in the Duffy (T-33C) locus is reported. Its near fixation in various populations suggest is no longer under natural selection, and that current distribution is possibly a relic of distant extreme selection combined with genetic drift during the out of Africa. We put this difference into the utility to infer the ancestral state of ambiguous loci in different populations. Published by Elsevier B.V. 2020-12 2020-08-11 /pmc/articles/PMC7418637/ /pubmed/32837914 http://dx.doi.org/10.1016/j.mgene.2020.100782 Text en © 2020 Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ali Albsheer, Musab M.
Hussien, Ayman
Kwiatkowski, Dominic
Hamid, Muzamil Mahdi Abdel
Ibrahim, Muntaser E.
The Duffy T-33C is an insightful marker of human history and admixture
title The Duffy T-33C is an insightful marker of human history and admixture
title_full The Duffy T-33C is an insightful marker of human history and admixture
title_fullStr The Duffy T-33C is an insightful marker of human history and admixture
title_full_unstemmed The Duffy T-33C is an insightful marker of human history and admixture
title_short The Duffy T-33C is an insightful marker of human history and admixture
title_sort duffy t-33c is an insightful marker of human history and admixture
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418637/
https://www.ncbi.nlm.nih.gov/pubmed/32837914
http://dx.doi.org/10.1016/j.mgene.2020.100782
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