Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

COVID-19 affects vulnerable populations including elderly individuals and patients with cancer. Natural Killer (NK) cells and innate-immune TRAIL suppress transformed and virally-infected cells. ACE2, and TMPRSS2 protease promote SARS-CoV-2 infectivity, while inflammatory cytokines IL-6, or G-CSF wo...

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Detalles Bibliográficos
Autores principales: Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Lee, Chun Geun, Elias, Jack A., Campbell, Kerry S., Naik, Mandar T., Atwood, Walter J., Youssef, Emile, Pachter, Jonathan A., Navaraj, Arunasalam, Seyhan, Attila A., Liang, Olin, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418728/
https://www.ncbi.nlm.nih.gov/pubmed/32793908
http://dx.doi.org/10.1101/2020.08.02.230839

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