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SARS-CoV-2 serological testing changes disease management in a PCR-negative patient
Since the beginning of the COVID-19 pandemic, healthcare providers worldwide have faced many obstacles in the diagnostic evaluation of patients for severe acute respiratory syndrome coronavirus 2, the causative virus. Even with the application of statistical inference by Bayes’ theorem to estimate t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418774/ https://www.ncbi.nlm.nih.gov/pubmed/32784236 http://dx.doi.org/10.1136/bcr-2020-237239 |
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author | Knight, Dacre Irizarry-Alvarado, Joan |
author_facet | Knight, Dacre Irizarry-Alvarado, Joan |
author_sort | Knight, Dacre |
collection | PubMed |
description | Since the beginning of the COVID-19 pandemic, healthcare providers worldwide have faced many obstacles in the diagnostic evaluation of patients for severe acute respiratory syndrome coronavirus 2, the causative virus. Even with the application of statistical inference by Bayes’ theorem to estimate the probability of a diagnosis, with and without testing capabilities, some cases may still carry a degree of uncertainty. This has important implications for limiting the spread of disease. The basis for isolation and quarantine is a known diagnosis. This case is an example of a diagnostic conundrum that required more thorough use of testing methods, particularly serological testing, to guide the isolation recommendations for a patient with COVID-19. This will be helpful to other diagnosticians by providing an example of how serological findings may be effectively applied in the course of individual COVID-19 management. |
format | Online Article Text |
id | pubmed-7418774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-74187742020-08-18 SARS-CoV-2 serological testing changes disease management in a PCR-negative patient Knight, Dacre Irizarry-Alvarado, Joan BMJ Case Rep New Disease Since the beginning of the COVID-19 pandemic, healthcare providers worldwide have faced many obstacles in the diagnostic evaluation of patients for severe acute respiratory syndrome coronavirus 2, the causative virus. Even with the application of statistical inference by Bayes’ theorem to estimate the probability of a diagnosis, with and without testing capabilities, some cases may still carry a degree of uncertainty. This has important implications for limiting the spread of disease. The basis for isolation and quarantine is a known diagnosis. This case is an example of a diagnostic conundrum that required more thorough use of testing methods, particularly serological testing, to guide the isolation recommendations for a patient with COVID-19. This will be helpful to other diagnosticians by providing an example of how serological findings may be effectively applied in the course of individual COVID-19 management. BMJ Publishing Group 2020-08-11 /pmc/articles/PMC7418774/ /pubmed/32784236 http://dx.doi.org/10.1136/bcr-2020-237239 Text en © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.https://bmj.com/coronavirus/usage |
spellingShingle | New Disease Knight, Dacre Irizarry-Alvarado, Joan SARS-CoV-2 serological testing changes disease management in a PCR-negative patient |
title | SARS-CoV-2 serological testing changes disease management in a PCR-negative patient |
title_full | SARS-CoV-2 serological testing changes disease management in a PCR-negative patient |
title_fullStr | SARS-CoV-2 serological testing changes disease management in a PCR-negative patient |
title_full_unstemmed | SARS-CoV-2 serological testing changes disease management in a PCR-negative patient |
title_short | SARS-CoV-2 serological testing changes disease management in a PCR-negative patient |
title_sort | sars-cov-2 serological testing changes disease management in a pcr-negative patient |
topic | New Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418774/ https://www.ncbi.nlm.nih.gov/pubmed/32784236 http://dx.doi.org/10.1136/bcr-2020-237239 |
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