Cargando…

SARS-CoV-2 serological testing changes disease management in a PCR-negative patient

Since the beginning of the COVID-19 pandemic, healthcare providers worldwide have faced many obstacles in the diagnostic evaluation of patients for severe acute respiratory syndrome coronavirus 2, the causative virus. Even with the application of statistical inference by Bayes’ theorem to estimate t...

Descripción completa

Detalles Bibliográficos
Autores principales: Knight, Dacre, Irizarry-Alvarado, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418774/
https://www.ncbi.nlm.nih.gov/pubmed/32784236
http://dx.doi.org/10.1136/bcr-2020-237239
_version_ 1783569754106101760
author Knight, Dacre
Irizarry-Alvarado, Joan
author_facet Knight, Dacre
Irizarry-Alvarado, Joan
author_sort Knight, Dacre
collection PubMed
description Since the beginning of the COVID-19 pandemic, healthcare providers worldwide have faced many obstacles in the diagnostic evaluation of patients for severe acute respiratory syndrome coronavirus 2, the causative virus. Even with the application of statistical inference by Bayes’ theorem to estimate the probability of a diagnosis, with and without testing capabilities, some cases may still carry a degree of uncertainty. This has important implications for limiting the spread of disease. The basis for isolation and quarantine is a known diagnosis. This case is an example of a diagnostic conundrum that required more thorough use of testing methods, particularly serological testing, to guide the isolation recommendations for a patient with COVID-19. This will be helpful to other diagnosticians by providing an example of how serological findings may be effectively applied in the course of individual COVID-19 management.
format Online
Article
Text
id pubmed-7418774
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-74187742020-08-18 SARS-CoV-2 serological testing changes disease management in a PCR-negative patient Knight, Dacre Irizarry-Alvarado, Joan BMJ Case Rep New Disease Since the beginning of the COVID-19 pandemic, healthcare providers worldwide have faced many obstacles in the diagnostic evaluation of patients for severe acute respiratory syndrome coronavirus 2, the causative virus. Even with the application of statistical inference by Bayes’ theorem to estimate the probability of a diagnosis, with and without testing capabilities, some cases may still carry a degree of uncertainty. This has important implications for limiting the spread of disease. The basis for isolation and quarantine is a known diagnosis. This case is an example of a diagnostic conundrum that required more thorough use of testing methods, particularly serological testing, to guide the isolation recommendations for a patient with COVID-19. This will be helpful to other diagnosticians by providing an example of how serological findings may be effectively applied in the course of individual COVID-19 management. BMJ Publishing Group 2020-08-11 /pmc/articles/PMC7418774/ /pubmed/32784236 http://dx.doi.org/10.1136/bcr-2020-237239 Text en © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ. This article is made freely available for use in accordance with BMJ’s website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained.https://bmj.com/coronavirus/usage
spellingShingle New Disease
Knight, Dacre
Irizarry-Alvarado, Joan
SARS-CoV-2 serological testing changes disease management in a PCR-negative patient
title SARS-CoV-2 serological testing changes disease management in a PCR-negative patient
title_full SARS-CoV-2 serological testing changes disease management in a PCR-negative patient
title_fullStr SARS-CoV-2 serological testing changes disease management in a PCR-negative patient
title_full_unstemmed SARS-CoV-2 serological testing changes disease management in a PCR-negative patient
title_short SARS-CoV-2 serological testing changes disease management in a PCR-negative patient
title_sort sars-cov-2 serological testing changes disease management in a pcr-negative patient
topic New Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418774/
https://www.ncbi.nlm.nih.gov/pubmed/32784236
http://dx.doi.org/10.1136/bcr-2020-237239
work_keys_str_mv AT knightdacre sarscov2serologicaltestingchangesdiseasemanagementinapcrnegativepatient
AT irizarryalvaradojoan sarscov2serologicaltestingchangesdiseasemanagementinapcrnegativepatient