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Oxazaphosphorines combined with immune checkpoint blockers: dose-dependent tuning between immune and cytotoxic effects

BACKGROUND: Oxazaphosphorines (cyclophosphamide (CPA), ifosfamide (IFO)) are major alkylating agents of polychemotherapy protocols but limiting their toxicity and increasing their efficacy could be of major interest. Oxazaphosphorines are prodrugs that require an activation by cytochrome P450 (CYP)....

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Detalles Bibliográficos
Autores principales:	Delahousse, Julia, Skarbek, Charles, Desbois, Mélanie, Perfettini, Jean-Luc, Chaput, Nathalie, Paci, Angelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418776/ https://www.ncbi.nlm.nih.gov/pubmed/32784216 http://dx.doi.org/10.1136/jitc-2020-000916

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