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The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort
BACKGROUND AND AIMS: Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality. We retrospectively anal...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418787/ https://www.ncbi.nlm.nih.gov/pubmed/32988724 http://dx.doi.org/10.1016/j.numecd.2020.07.047 |
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author | Biscarini, Simona Colaneri, Marta Ludovisi, Serena Seminari, Elena Pieri, Teresa C. Valsecchi, Pietro Gallazzi, Ilaria Giusti, Emanuele Cammà, Calogero Zuccaro, Valentina Mondelli, Mario U. |
author_facet | Biscarini, Simona Colaneri, Marta Ludovisi, Serena Seminari, Elena Pieri, Teresa C. Valsecchi, Pietro Gallazzi, Ilaria Giusti, Emanuele Cammà, Calogero Zuccaro, Valentina Mondelli, Mario U. |
author_sort | Biscarini, Simona |
collection | PubMed |
description | BACKGROUND AND AIMS: Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality. We retrospectively analyzed a COVID-19 cohort recruited during the first 40 days of the epidemic in Italy. We examined the association between obesity and 30-day mortality, admission to ICU, mortality and length of hospital stay in patients with COVID-19. METHODS AND RESULTS: Demographic, clinical and outcome data were retrospectively analyzed in 331 patients with COVID-19 admitted to hospital between 21 February and 31 March 2020. The predictive effect of obesity on mortality was assessed using a Cox proportional-hazard regression model, its effect on ICU admission and mortality in the ICU using logistic regressions, and its effect on length of hospital stay using a linear regression. Seventy-four of 331 patients had a BMI ≥30 kg/m(2). Among obese patients, 21 (28.4%) required admission in ICU and 25 died (33.8%). After controlling for sex, age, comorbidities and clinical data, obesity was not significantly associated with mortality, mortality in ICU and length of hospital stay. The effect of obesity on ICU admission remained significant after controlling for sex, age, interstitial lung disease, heart disease and serum C-reactive protein. CONCLUSIONS: Obese patients with COVID-19 were more likely to be admitted to ICU than non-obese patients. However, there were no significant differences in mortality between the two groups. |
format | Online Article Text |
id | pubmed-7418787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74187872020-08-12 The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort Biscarini, Simona Colaneri, Marta Ludovisi, Serena Seminari, Elena Pieri, Teresa C. Valsecchi, Pietro Gallazzi, Ilaria Giusti, Emanuele Cammà, Calogero Zuccaro, Valentina Mondelli, Mario U. Nutr Metab Cardiovasc Dis Article BACKGROUND AND AIMS: Obesity has been suggested as a possible risk factor for a more severe course of COVID-19; however, conclusive evidence is lacking and few studies have investigated the role of BMI as a risk factor for admission to intensive care unit (ICU) and mortality. We retrospectively analyzed a COVID-19 cohort recruited during the first 40 days of the epidemic in Italy. We examined the association between obesity and 30-day mortality, admission to ICU, mortality and length of hospital stay in patients with COVID-19. METHODS AND RESULTS: Demographic, clinical and outcome data were retrospectively analyzed in 331 patients with COVID-19 admitted to hospital between 21 February and 31 March 2020. The predictive effect of obesity on mortality was assessed using a Cox proportional-hazard regression model, its effect on ICU admission and mortality in the ICU using logistic regressions, and its effect on length of hospital stay using a linear regression. Seventy-four of 331 patients had a BMI ≥30 kg/m(2). Among obese patients, 21 (28.4%) required admission in ICU and 25 died (33.8%). After controlling for sex, age, comorbidities and clinical data, obesity was not significantly associated with mortality, mortality in ICU and length of hospital stay. The effect of obesity on ICU admission remained significant after controlling for sex, age, interstitial lung disease, heart disease and serum C-reactive protein. CONCLUSIONS: Obese patients with COVID-19 were more likely to be admitted to ICU than non-obese patients. However, there were no significant differences in mortality between the two groups. The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. 2020-10-30 2020-08-11 /pmc/articles/PMC7418787/ /pubmed/32988724 http://dx.doi.org/10.1016/j.numecd.2020.07.047 Text en © 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Biscarini, Simona Colaneri, Marta Ludovisi, Serena Seminari, Elena Pieri, Teresa C. Valsecchi, Pietro Gallazzi, Ilaria Giusti, Emanuele Cammà, Calogero Zuccaro, Valentina Mondelli, Mario U. The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort |
title | The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort |
title_full | The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort |
title_fullStr | The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort |
title_full_unstemmed | The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort |
title_short | The obesity paradox: Analysis from the SMAtteo COvid-19 REgistry (SMACORE) cohort |
title_sort | obesity paradox: analysis from the smatteo covid-19 registry (smacore) cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418787/ https://www.ncbi.nlm.nih.gov/pubmed/32988724 http://dx.doi.org/10.1016/j.numecd.2020.07.047 |
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