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Acute transverse myelitis in COVID-19 infection

A 60-year-old man presented to hospital with bilateral lower limb weakness, urinary retention and constipation. He had been diagnosed with COVID-19 10 days prior. Clinical examination revealed global weakness, increased tone, hyperreflexia and patchy paresthesia in his lower limbs bilaterally. Preli...

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Detalles Bibliográficos
Autores principales: Chow, Chian Chiang Nicholas, Magnussen, John, Ip, Jerome, Su, Yuen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418849/
https://www.ncbi.nlm.nih.gov/pubmed/32784242
http://dx.doi.org/10.1136/bcr-2020-236720
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author Chow, Chian Chiang Nicholas
Magnussen, John
Ip, Jerome
Su, Yuen
author_facet Chow, Chian Chiang Nicholas
Magnussen, John
Ip, Jerome
Su, Yuen
author_sort Chow, Chian Chiang Nicholas
collection PubMed
description A 60-year-old man presented to hospital with bilateral lower limb weakness, urinary retention and constipation. He had been diagnosed with COVID-19 10 days prior. Clinical examination revealed global weakness, increased tone, hyperreflexia and patchy paresthesia in his lower limbs bilaterally. Preliminary blood tests performed revealed a mildly elevated C reactive protein and erythrocyte sedimentation rate but was otherwise unremarkable. MRI scan of his whole spine demonstrated hyperintense T2 signal centrally from T7 to T10, suggestive of acute transverse myelitis. A lumbar puncture showed elevated protein count but normal glucose and white blood cell count. Serological testing for other viruses was negative. His neurological symptoms improved significantly after treatment with intravenous methylprednisone. This case highlights a potential neurological complication of COVID-19 infection.
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spelling pubmed-74188492020-08-18 Acute transverse myelitis in COVID-19 infection Chow, Chian Chiang Nicholas Magnussen, John Ip, Jerome Su, Yuen BMJ Case Rep Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect A 60-year-old man presented to hospital with bilateral lower limb weakness, urinary retention and constipation. He had been diagnosed with COVID-19 10 days prior. Clinical examination revealed global weakness, increased tone, hyperreflexia and patchy paresthesia in his lower limbs bilaterally. Preliminary blood tests performed revealed a mildly elevated C reactive protein and erythrocyte sedimentation rate but was otherwise unremarkable. MRI scan of his whole spine demonstrated hyperintense T2 signal centrally from T7 to T10, suggestive of acute transverse myelitis. A lumbar puncture showed elevated protein count but normal glucose and white blood cell count. Serological testing for other viruses was negative. His neurological symptoms improved significantly after treatment with intravenous methylprednisone. This case highlights a potential neurological complication of COVID-19 infection. BMJ Publishing Group 2020-08-11 /pmc/articles/PMC7418849/ /pubmed/32784242 http://dx.doi.org/10.1136/bcr-2020-236720 Text en © BMJ Publishing Group Limited 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect
Chow, Chian Chiang Nicholas
Magnussen, John
Ip, Jerome
Su, Yuen
Acute transverse myelitis in COVID-19 infection
title Acute transverse myelitis in COVID-19 infection
title_full Acute transverse myelitis in COVID-19 infection
title_fullStr Acute transverse myelitis in COVID-19 infection
title_full_unstemmed Acute transverse myelitis in COVID-19 infection
title_short Acute transverse myelitis in COVID-19 infection
title_sort acute transverse myelitis in covid-19 infection
topic Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418849/
https://www.ncbi.nlm.nih.gov/pubmed/32784242
http://dx.doi.org/10.1136/bcr-2020-236720
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