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Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus

Immunodominance is recognized as a key factor in the antigenic drift of seasonal influenza viruses. In the immunodominance model, each individual in a population predominantly responds to a single epitope among the five antigenic epitopes of the viral hemagglutinin (HA), driving escape mutations one...

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Autores principales: Ketklao, S., Boonarkart, C., Phakaratsakul, S., Auewarakul, P., Suptawiwat, Ornpreya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418886/
https://www.ncbi.nlm.nih.gov/pubmed/32783078
http://dx.doi.org/10.1007/s00705-020-04758-5
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author Ketklao, S.
Boonarkart, C.
Phakaratsakul, S.
Auewarakul, P.
Suptawiwat, Ornpreya
author_facet Ketklao, S.
Boonarkart, C.
Phakaratsakul, S.
Auewarakul, P.
Suptawiwat, Ornpreya
author_sort Ketklao, S.
collection PubMed
description Immunodominance is recognized as a key factor in the antigenic drift of seasonal influenza viruses. In the immunodominance model, each individual in a population predominantly responds to a single epitope among the five antigenic epitopes of the viral hemagglutinin (HA), driving escape mutations one at a time, and sequential mutations in multiple individuals who respond to different epitopes eventually generate a drifted strain with mutations in epitopes that are targeted by a majority of the population. A focused antibody response to the Sa epitope in people born between 1965 and 1979 was believed to contribute to a mutation at HA residue 163 and the first antigenic drift of the 2009 pandemic influenza A H1N1 virus. A serine-to-threonine mutation at HA residue 185 in the Sb epitope emerged in 2010 even before the 163 mutation. We show here that a large fraction of the population in 2010-2011 had responses to the Sb epitope, as shown by 47% of tested sera having altered titers to the S185T mutant. Responses to the Sb epitope showed an age-specific trend similar to that found for the response to Sa epitope in these subjects. Together, the focused responses to Sa and Sb epitopes may have driven the first antigenic drift of the 2009 pandemic H1N1 virus.
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spelling pubmed-74188862020-08-12 Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus Ketklao, S. Boonarkart, C. Phakaratsakul, S. Auewarakul, P. Suptawiwat, Ornpreya Arch Virol Original Article Immunodominance is recognized as a key factor in the antigenic drift of seasonal influenza viruses. In the immunodominance model, each individual in a population predominantly responds to a single epitope among the five antigenic epitopes of the viral hemagglutinin (HA), driving escape mutations one at a time, and sequential mutations in multiple individuals who respond to different epitopes eventually generate a drifted strain with mutations in epitopes that are targeted by a majority of the population. A focused antibody response to the Sa epitope in people born between 1965 and 1979 was believed to contribute to a mutation at HA residue 163 and the first antigenic drift of the 2009 pandemic influenza A H1N1 virus. A serine-to-threonine mutation at HA residue 185 in the Sb epitope emerged in 2010 even before the 163 mutation. We show here that a large fraction of the population in 2010-2011 had responses to the Sb epitope, as shown by 47% of tested sera having altered titers to the S185T mutant. Responses to the Sb epitope showed an age-specific trend similar to that found for the response to Sa epitope in these subjects. Together, the focused responses to Sa and Sb epitopes may have driven the first antigenic drift of the 2009 pandemic H1N1 virus. Springer Vienna 2020-08-11 2020 /pmc/articles/PMC7418886/ /pubmed/32783078 http://dx.doi.org/10.1007/s00705-020-04758-5 Text en © Springer-Verlag GmbH Austria, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Original Article
Ketklao, S.
Boonarkart, C.
Phakaratsakul, S.
Auewarakul, P.
Suptawiwat, Ornpreya
Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus
title Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus
title_full Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus
title_fullStr Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus
title_full_unstemmed Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus
title_short Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus
title_sort responses to the sb epitope contributed to antigenic drift of the influenza a 2009 h1n1 virus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418886/
https://www.ncbi.nlm.nih.gov/pubmed/32783078
http://dx.doi.org/10.1007/s00705-020-04758-5
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