Untargeted metabolomics reveal dysregulations in sugar, methionine, and tyrosine pathways in the prodromal state of AD

INTRODUCTION: Altered metabolism may occur years before clinical manifestations of Alzheimer's disease (AD). We used untargeted metabolomics on the cerebrospinal fluid of patients with mild cognitive impairment (MCI) to uncover metabolomic derangements. METHODS: CSF from 92 normal controls and...

Descripción completa

Detalles Bibliográficos
Autores principales: Hajjar, Ihab, Liu, Chang, Jones, Dean P., Uppal, Karan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cerebrospinal Fluid Biomarkers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418891/
https://www.ncbi.nlm.nih.gov/pubmed/32793799
http://dx.doi.org/10.1002/dad2.12064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418891/
https://www.ncbi.nlm.nih.gov/pubmed/32793799
http://dx.doi.org/10.1002/dad2.12064

Ejemplares similares