Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

Two-component, self-assembling nanoparticles represent a versatile platform for multivalent presentation of viral antigens. Computational design of protein nanoparticles with differing sizes and geometries enables combination with antigens of choice to test novel multimerization concepts in immuniza...

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Detalles Bibliográficos
Autores principales: Antanasijevic, Aleksandar, Ueda, George, Brouwer, Philip J. M., Copps, Jeffrey, Huang, Deli, Allen, Joel D., Cottrell, Christopher A., Yasmeen, Anila, Sewall, Leigh M., Bontjer, Ilja, Ketas, Thomas J., Turner, Hannah L., Berndsen, Zachary T., Montefiori, David C., Klasse, Per Johan, Crispin, Max, Nemazee, David, Moore, John P., Sanders, Rogier W., King, Neil P., Baker, David, Ward, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418955/
https://www.ncbi.nlm.nih.gov/pubmed/32780770
http://dx.doi.org/10.1371/journal.ppat.1008665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418955/
https://www.ncbi.nlm.nih.gov/pubmed/32780770
http://dx.doi.org/10.1371/journal.ppat.1008665

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