Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

In clinical trials, animal and cell line models are often used to evaluate the potential toxic effects of a novel compound or candidate drug before progressing to human trials. However, relating the results of animal and in vitro model exposures to relevant clinical outcomes in the human in vivo sys...

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Detalles Bibliográficos
Autores principales: O’Donovan, Shauna D., Driessens, Kurt, Lopatta, Daniel, Wimmenauer, Florian, Lukas, Alexander, Neeven, Jelmer, Stumm, Tobias, Smirnov, Evgueni, Lenz, Michael, Ertaylan, Gokhan, Jennen, Danyel G. J., van Riel, Natal A. W., Cavill, Rachel, Peeters, Ralf L. M., de Kok, Theo M. C. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418976/
https://www.ncbi.nlm.nih.gov/pubmed/32780735
http://dx.doi.org/10.1371/journal.pone.0236392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418976/
https://www.ncbi.nlm.nih.gov/pubmed/32780735
http://dx.doi.org/10.1371/journal.pone.0236392

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