NHD2-15, a novel antagonist of Growth Factor Receptor-Bound Protein-2 (GRB2), inhibits leukemic proliferation

The majority of chronic myeloid leukemia (CML) cases are caused by a chromosomal translocation linking the breakpoint cluster region (BCR) gene to the Abelson murine leukemia viral oncogene-1 (ABL1), creating the mutant fusion protein BCR-ABL1. Downstream of BCR-ABL1 is growth factor receptor-bound...

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Detalles Bibliográficos
Autores principales: Lewis, Tina R., Smith, Jesse, Griffin, Kallie, Aguiar, Stephanie, Rueb, Kristen F., Holmberg-Douglas, Natalie, Sampson, Ellen M., Tomasetti, Skylar, Rodriguez, Sofia, Stachura, David L., Arpin, Carolynn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418987/
https://www.ncbi.nlm.nih.gov/pubmed/32780746
http://dx.doi.org/10.1371/journal.pone.0236839

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