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Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles

Emerging evidence has shown that dynamic crosstalk among cells in the tumor microenvironment modulates the progression and chemotherapeutic responses of cancer. Extracellular vesicles comprise a crucial form of intracellular communication through horizontal transfer of bioactive molecules, including...

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Detalles Bibliográficos
Autores principales: Zhang, Wei‐long, Liu, Yan, Jiang, Jian, Tang, Ya‐Jie, Tang, Ya‐ling, Liang, Xin‐hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419043/
https://www.ncbi.nlm.nih.gov/pubmed/32437078
http://dx.doi.org/10.1111/cas.14494
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author Zhang, Wei‐long
Liu, Yan
Jiang, Jian
Tang, Ya‐Jie
Tang, Ya‐ling
Liang, Xin‐hua
author_facet Zhang, Wei‐long
Liu, Yan
Jiang, Jian
Tang, Ya‐Jie
Tang, Ya‐ling
Liang, Xin‐hua
author_sort Zhang, Wei‐long
collection PubMed
description Emerging evidence has shown that dynamic crosstalk among cells in the tumor microenvironment modulates the progression and chemotherapeutic responses of cancer. Extracellular vesicles comprise a crucial form of intracellular communication through horizontal transfer of bioactive molecules, including long non–coding RNA (lncRNA), to neighboring cells. Three main types of extracellular vesicles are exosomes, microvesicles and apoptotic bodies, exhibiting a wide range of sizes and different biogenesis. Over the last decade, dysregulation of extracellular vesicle lncRNA has been revealed to remodel the tumor microenvironment and induce aggressive phenotypes of tumor cells, thereby facilitating tumor growth and development. This review will focus on extracellular vesicle lncRNA‐mediated crosstalk between tumor cells and recipient cells, including tumor cells as well as stromal cells in the tumor microenvironment, and overview the mechanisms by which lncRNA are selectively sorted into extracellular vesicles, which may pave the way for their clinical application in cancer diagnosis and treatment.
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spelling pubmed-74190432020-08-12 Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles Zhang, Wei‐long Liu, Yan Jiang, Jian Tang, Ya‐Jie Tang, Ya‐ling Liang, Xin‐hua Cancer Sci Review Articles Emerging evidence has shown that dynamic crosstalk among cells in the tumor microenvironment modulates the progression and chemotherapeutic responses of cancer. Extracellular vesicles comprise a crucial form of intracellular communication through horizontal transfer of bioactive molecules, including long non–coding RNA (lncRNA), to neighboring cells. Three main types of extracellular vesicles are exosomes, microvesicles and apoptotic bodies, exhibiting a wide range of sizes and different biogenesis. Over the last decade, dysregulation of extracellular vesicle lncRNA has been revealed to remodel the tumor microenvironment and induce aggressive phenotypes of tumor cells, thereby facilitating tumor growth and development. This review will focus on extracellular vesicle lncRNA‐mediated crosstalk between tumor cells and recipient cells, including tumor cells as well as stromal cells in the tumor microenvironment, and overview the mechanisms by which lncRNA are selectively sorted into extracellular vesicles, which may pave the way for their clinical application in cancer diagnosis and treatment. John Wiley and Sons Inc. 2020-06-27 2020-08 /pmc/articles/PMC7419043/ /pubmed/32437078 http://dx.doi.org/10.1111/cas.14494 Text en © 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Zhang, Wei‐long
Liu, Yan
Jiang, Jian
Tang, Ya‐Jie
Tang, Ya‐ling
Liang, Xin‐hua
Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles
title Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles
title_full Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles
title_fullStr Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles
title_full_unstemmed Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles
title_short Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles
title_sort extracellular vesicle long non–coding rna‐mediated crosstalk in the tumor microenvironment: tiny molecules, huge roles
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419043/
https://www.ncbi.nlm.nih.gov/pubmed/32437078
http://dx.doi.org/10.1111/cas.14494
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